29113-70-0Relevant academic research and scientific papers
Visible-Light Induced Direct Synthesis of Polysubstituted Furans from Cyclopropyl Ketones
Feng, Liyan,Yan, Hang,Yang, Chao,Chen, Dafa,Xia, Wujiong
, p. 7008 - 7022 (2016/08/30)
In this article, a photoredox protocol for the synthesis of furans via oxidative coupling of olefin generated in situ from cyclopropyl ketones with ketonic oxygen atom is presented. Moreover, bromination of furans in the presence of overstoichiometric oxidant has been achieved with high regioselectivity.
Copper-Catalyzed Coupling of 2-Siloxy-1-alkenes and Diazocarbonyl Compounds: Approach to Multisubstituted Furans, Pyrroles, and Thiophenes
Tan, Wei Wen,Yoshikai, Naohiko
, p. 5566 - 5573 (2016/07/14)
We report herein copper(II)-catalyzed cyclization reactions of silyl enol ethers derived from methyl ketones with α-diazo-β-ketoesters or α-diazoketones to afford 2-siloxy-2,3-dihydrofuran derivatives or 2,3,5-trisubstituted furans, respectively, under mild conditions. The former cyclization products serve as versatile 1,4-diketone surrogates, allowing facile preparation of 2,3,5-trisubstituted furans, pyrroles, and thiophenes.
