29124-65-0Relevant academic research and scientific papers
General and efficient one-pot synthesis of N-substituted 7-bromo-2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-ones
Li, Yang,Li, Kai,Gao, Wentao
, p. 200 - 205 (2016)
[Figure not available: see fulltext.]A simple and general synthesis of a series of quinoline-based isoindolin-l-ones, namely N-substituted 7-bromo-2,3-dihydro-1H-pyrrolo-[3,4-b]quinolin-1-ones through a one-pot reaction of ethyl 6-bromo-2-(chloromethyl)qu
Preparation method of ethyl quinoline carboxylate
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Paragraph 0007, (2020/01/12)
The invention discloses a preparation method of ethyl quinoline carboxylate. The method comprises the following steps: dissolving o-aminobenzaldehyde in acetic anhydride, adding water, performing heating to 75 DEG C and carrying out a reaction for 5 h, th
Structural Simplification of a Tetrahydroquinoline-Core Peptidomimetic μ-Opioid Receptor (MOR) Agonist/δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability
Henry, Sean P.,Fernandez, Thomas J.,Anand, Jessica P.,Griggs, Nicholas W.,Traynor, John R.,Mosberg, Henry I.
, p. 4142 - 4157 (2019/05/06)
We have previously reported a series of μ-opioid receptor (MOR) agonist/δ-opioid receptor (DOR) antagonist ligands to serve as potential nonaddictive opioid analgesics. These ligands have been shown to be active in vivo, do not manifest withdrawal syndromes or reward behavior in conditioned-place preference assays in mice, and do not produce dependence. Although these attributes are promising, these analogues exhibit poor metabolic stability in mouse liver microsomes, likely due to the central tetrahydroquinoline scaffold in this series. As such, a structure-activity relationship (SAR) campaign was pursued to improve their metabolic stability. This resulted in a shift from our original bicyclic tetrahydroquinoline core to a monocyclic benzylic-core system. By eliminating one of the rings in this scaffold and exploring the SAR of this new core, two promising analogues were discovered. These analogues (5l and 5m) had potency and efficacy values at MOR better or comparable to morphine, retained their DOR-antagonist properties, and showed a 10-fold improvement in metabolic stability.
