291275-36-0

Upstream product

• 1006300-24-8 (3-Chloro-5-methyl-phenyl)-(5-isopropyl-2,6-dimethoxy-pyrimidin-4-yl)-methanone 

Downstream Products

• 1006300-25-9 C₂₀H₁₈Cl₂N₄O₃ 
• 1006300-73-7 C₂₂H₂₂ClN₃O₄ 
• 1006300-74-8 1-[2-chloro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl]-6-(3-chloro-5-methyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione 
• 1006300-76-0 N-{4-[6-(3-chloro-5-methyl-benzoyl)-5-isopropyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-pyridin-2-yl}-acetamide 
• 1006300-80-6 6-(3-chloro-5-methyl-benzoyl)-1-(2,6-difluoro-pyridin-4-ylmethyl)-5-isopropyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Novel HIV reverse transcriptase inhibitors

The invention is related to compounds of Formula (I), (II), or (III): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof

2,4-pyrimidinedione derivatives of formula (I) having high antiviral activity against wild-type and mutant HIV-1 and low toxicity are useful for treating AIDS (I) wherein: R1is a C6-10aryl or C3-10heteroaryl group optional