291276-01-2Relevant articles and documents
A facile synthesis of polysubstituted pyrroles
Dieter, R. Karl,Yu, Huayun
, p. 2283 - 2286 (2000)
(equation presented) α-Aminoalkylcuprates prepared from CuX·2LiCI (X = Cl, CN) and 1 equiv of an α-lithiocarbamate undergo conjugate addition reactions to α,β-alkynyl ketones in moderate to good yields, affording E:Z mixtures of α,β-enones. Treatment of the conjugate adducts with PhOH/TMSCI in CH2CI2 effected carbamate deprotection and cyclization to afford a flexible two-step synthesis of substituted pyrroles.
FUSED PYRROLE COMPOUNDS, PHARMACEUTICAL AGENTS CONTAINING THE SAME, AND THE USE THEREOF
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Page 46, (2010/02/04)
The present invention relates to fused pyrrole compounds of the formula 1. in which at least one of the radicals R1, R2, R3 is 4-sulphur-substituted phenyl. These compounds are in particular pyrrolizines, indolizines and heteroanalogues having selective inhibitory action on isoenzyme-2 of prostaglandin H synthase (COX-2). The invention also relates to pharmaceutical compositions which contain these compounds; and the use of these compounds for the treatment of disorders of the rheumatic type.