291312-95-3Relevant academic research and scientific papers
Cyclic Tetrapeptides Bearing a Sulfhydryl Group Potently Inhibit Histone Deacetylases
Nishino, Norikazu,Jose, Binoy,Okamura, Shinji,Ebisusaki, Shutoku,Kato, Tamaki,Sumida, Yuko,Yoshida, Minoru
, p. 5079 - 5082 (2007/10/03)
(Equation presented) New inhibitors of histone deacetylase (HDAC) containing a sulfhydryl group were designed on the basis of the corresponding hydroxamic acid (CHAP31) and FK228. Their disulfide dimers and hybrids exhibited potent HDAC inhibitory activity in vivo with potential as anticancer prodrugs.
