291313-75-2

Upstream product

• 252953-35-8 (R)-N-(tert-butoxycarbonyl)-4-formyl-2,2,4-trimethyl-3-oxazolidine 

Downstream Products

• 291313-78-5 (1R,7aR)-1-phenyl-5,5,7a-trimethyl-2,6-dioxa-4-azapentalen-3-one 
• 291313-76-3 (1S,7aR)-1-phenyl-5,5,7a-trimethyl-2,6-dioxa-4-azapentalen-3-one 
• 291313-84-3 (4R,5R)-4-(hydroxymethyl)-4-methyl-5-phenyl-3-oxazolidin-2-one 
• 291313-83-2 (4R,5S)-4-(hydroxymethyl)-4-methyl-5-phenyl-3-oxazolidin-2-one 

Relevant academic research and scientific papers

Asymmetric synthesis of all isomers of α-methyl-β-phenylserine

This report describes the synthesis of enantiomerically pure (2R,3R)-, (2R,3S)-, (2S,3S)- and (2S,3R)-2-amino-3-hydroxy-2-methyl-3-phenylpropanoic acids, four quaternary α-amino acids, using a stereodivergent synthetic route and starting from (S)- and (R)-N-Boc-N,O-isopropylidene-α-methylserinals. The key step involves the asymmetric Grignard additions to the above chiral aldehydes, in which high levels of asymmetric induction are observed. Copyright (C) 2000 Elsevier Science Ltd.