29134-22-3Relevant academic research and scientific papers
Br?nsted acid mediated cyclizations of ortho-aryl(ethynyl)pyrimidines
Shestakov, Aleksandr N.,Pankova, Alena S.,Golubev, Pavel,Khlebnikov, Alexander F.,Kuznetsov, Mikhail A.
supporting information, p. 3939 - 3948 (2017/06/14)
A high-yielding procedure for the synthesis of 5-aryl-4-(arylethynyl)pyrimidines from easily available 2-aryl-3-hydroxyacrylates is reported. These pyrimidines readily undergo cyclization in strong Br?nsted acids and, depending on the substitution in alky
Chemoselective Reduction of α-Cyano Carbonyl Compounds: Application to the Preparation of Heterocycles
Pollack, Scott R.,Kuethe, Jeffrey T.
, p. 6388 - 6391 (2016/12/23)
β-Aminoacrylates are reactive intermediates that are useful building blocks in synthesis. General methods for their preparation typically afford α and β disubstitution patterns or β only. Molecules with only α-substituents (β-hydrogen) are much less well-known. A chemoselective reductive tautomerization of α-cyanoacetates, using DIBAL-H, has been developed to access these valuable synthons. α,β-Unsaturated cyanoacetates and α-cyanoketones can, also, be selectively reduced via this methodology. A series of heterocycles were prepared using these β-enamino carbonyl compounds.
