29134-93-8Relevant academic research and scientific papers
Kinetically controlled diastereoselective synthesis of CPS124, a carnitine monothiophosphate
Prasad, Kapa,Xu, David D.,Tempkin, Orin,Villhauer, Edwin B.,Repic, Oljan
, p. 743 - 749 (2013/09/05)
An expedient synthesis of CPS124 (1) is described using the diastereoselective reaction of the in situ generated dichlorophosphite 6 with L-carnitine tetrafluoroborate salt 7 under kinetic control as the key step. Alkylations of resorcinol 2 and its benzoate 13 are discussed. The use of α-cellulose as a support for solids that are difficult to filter or low melting is presented.
