29137-44-8Relevant academic research and scientific papers
Synthesis of bisboron compounds and their strong inhibitory activity on store-operated calcium entry
Suzuki, Akinobu Z.,Ozaki, Shoichiro,Goto, Jun-Ichi,Mikoshiba, Katsuhiko
experimental part, p. 1395 - 1398 (2010/06/19)
Store-operated calcium entry (SOCE) is an important mechanism for replenishing intracellular calcium stores and for sustaining calcium signaling. We developed a method for synthesis of bisboron compounds that have two borinic acids or their esters in one molecule. These compounds are analogues of 2-APB, which is widely used as a membrane-permeable SOCE inhibitor. Further, we examined the effect of the newly synthesized bisboron compounds on SOCE in Jurkat T cells. All the bisboron compounds showed strong inhibitory activity on SOCE, with IC50 values of less than 1 μM, which were 20-45 times lower than observed with 2-APB.
