291510-06-0

Upstream product

• 394706-11-7 [(2'R,3'R,4'R,5'R)-3',4'-dibenzyloxy-N-benzyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]carbaldehyde 
• 340970-04-9 (2R,3R,4R,5S)-3,4-dibenzyloxy-N-benzyloxycarbonyl-2'-O-tert-butyldiphenylsilyl-2,5-bis(hydroxymethyl)pyrrolidine 
• 394706-23-1 (E)-3-[(2'S,3'R,4'R,5'R)-3',4'-dibenzyloxy-N-benzyloxycarbonyl-5'-tert-butyldiphenylsilyloxymethylpyrrolidin-2'-yl]propenal 

Downstream Products

• 394706-21-9 (1R,2R,3R,7aS)-1,2-dibenzyloxy-3-hydroxymethylpyrrolizidine 

Relevant academic research and scientific papers

Polyhydroxylated pyrrolizidines. Part I: Short and highly stereocontrolled syntheses of hyacinthacines

Two short and highly stereocontrolled syntheses for 7a-epi-hyacinthacine A2 (7-deoxyalexine) 3 and 5,7a-diepi-hyacinthacine A3 4 are, respectively, reported herein. An appropriately protected polyhydroxypyrrolidine, (2R,3R,4R,5S)-3,4-dibenzyloxy-N-benzyloxycarbonyl-2′-O-tert- butyldiphenylsilyl-2,5-bis(hydroxymethyl)pyrrolidine 5, readily available from D-fructose, was chosen as the chiral starting material.