291525-23-0

Basic information

• Product Name: 3',5'-bis-O-(tert-butyldimethylsilyl)-5-(1-(3-phenyl-2-hydroxypropyl))-2'-deoxyuridine
• Synonyms: 3',5'-bis-O-(tert-butyldimethylsilyl)-5-(1-(3-phenyl-2-hydroxypropyl))-2'-deoxyuridine
• CAS NO: 291525-23-0
• Molecular Weight: 590.908
• Mol File: 291525-23-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3',5'-bis-O-(tert-butyldimethylsilyl)-5-(1-(3-phenyl-2-hydroxypropyl))-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-bis-O-(tert-butyldimethylsilyl)-5-(1-(3-phenyl-2-hydroxypropyl))-2'-deoxyuridine(291525-23-0)
• EPA Substance Registry System: 3',5'-bis-O-(tert-butyldimethylsilyl)-5-(1-(3-phenyl-2-hydroxypropyl))-2'-deoxyuridine(291525-23-0)

Safety Data

• Hazardous Substances Data: 291525-23-0(Hazardous Substances Data)

Upstream product

• 122-78-1 phenylacetaldehyde 
• 291525-18-3 3',5'-bis-O-(tert-butyldimethylsilyl)-5-(3-phenyl-2,2-(1,3-dithio))propyl-2'-deoxyuridine 
• 291525-17-2 3′,5′-bis-O-(tert-butyldimethylsilyl)-5-bromomethyl-2'-deoxyuridine 
• 40733-26-4 3',5'-O-di(tert-butyldimethylsilyl)thymidine 
• 31593-52-9 2-benzyl-1,3-dithiane 
• 291525-19-4 3',5'-bis-O-(tert-butyldimethylsilyl)-5-(3-phenyl-2-oxopropyl)-2'-deoxyuridine 

Relevant articles and documents

Independent Generation and Reactivity of 2′-Deoxy-5-methyleneuridin-5-yl, a Significant Reactive Intermediate Produced from Thymidine as a Result of Oxidative Stress

2′-Deoxy-5-methyleneuridin-5-yl (1) is produced in a variety of DNA damage processes and is believed to result in the formation of lesions that are mutagenic and refractory to enzymatic repair. 2′-Deoxy-5-methyleneuridin-5-yl (1) was independently generated under anaerobic conditions via Norrish Type I photocleavage during Pyrex filtered photolysis of the benzyl ketone 7. The radical (1) exhibits behavior consistent with that of a resonance-stabilized radical. The KIE for hydrogen atom transfer from t-BuSH was found to be 7.3 ± 1.7. Competition studies between radical recombination and hydrogen atom donors (2,5-dimethyltetrahydrofuran, kTrap = 46.1 ± 15.4 M-1 s-1; propan-2-ol, kTrap = 13.6 ± 3.5 M-1 s-1) chosen to mimic the carbohydrate components of 2′-deoxyribonucleotides suggest that 2′-deoxy-5-methyleneuridin-5-yl (1) may be able to transfer damage from the nucleobase to the deoxyribose of an adjacent nucleotide in DNA under hypoxic conditions.