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2917-02-4

6-amino-2-(propylsulfanyl)-4-pyrimidinol is an organic compound with the molecular formula C7H12N4OS. It is a derivative of pyrimidinol, featuring an amino group at the 6-position, a propylsulfanyl group at the 2-position, and a hydroxyl group at the 4-position. 6-amino-2-(propylsulfanyl)-4-pyrimidinol is known for its potential applications in the synthesis of various pharmaceuticals and agrochemicals, particularly as an intermediate in the production of certain antibiotics and antiviral drugs. Its chemical structure allows for the formation of hydrogen bonds and other interactions, which can be exploited in drug design to enhance binding affinity and specificity. The compound's properties, such as solubility and stability, can also be tailored for specific therapeutic applications.

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  • 2917-02-4 Structure

  • Basic information

    1. Product Name: 6-amino-2-(propylsulfanyl)-4-pyrimidinol
    2. Synonyms: 6-amino-2-(propylsulfanyl)-4-pyrimidinol
    3. CAS NO:2917-02-4
    4. Molecular Formula: C7H11N3OS
    5. Molecular Weight: 185.24674
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 2917-02-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-amino-2-(propylsulfanyl)-4-pyrimidinol(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-amino-2-(propylsulfanyl)-4-pyrimidinol(2917-02-4)
    11. EPA Substance Registry System: 6-amino-2-(propylsulfanyl)-4-pyrimidinol(2917-02-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2917-02-4(Hazardous Substances Data)

2917-02-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2917-02-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,1 and 7 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2917-02:
(6*2)+(5*9)+(4*1)+(3*7)+(2*0)+(1*2)=84
84 % 10 = 4
So 2917-02-4 is a valid CAS Registry Number.

2917-02-4Relevant articles and documents

Pyrimidinone derivative, preparation method thereof and application thereof in resisting mycobacterium tuberculosis infection

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Paragraph 0151-0156, (2020/11/25)

The invention discloses a pyrimidinone derivative, a preparation method thereof and an application thereof in resisting mycobacterium tuberculosis infection. The structure of the pyrimidinone derivative is shown as a formula I, wherein R1, m, X, Y, Z, R2

Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A3 adenosine receptor

Cosimelli, Barbara,Greco, Giovanni,Laneri, Sonia,Novellino, Ettore,Sacchi, Antonia,Collina, Simona,Rossi, Daniela,Cosconati, Sandro,Barresi, Elisabetta,Taliani, Sabrina,Trincavelli, Maria Letizia,Martini, Claudia

, p. 81 - 86 (2018/02/07)

Three A3 adenosine receptor (AR) antagonists (1-3) selected from 4-acylamino-6-alkyloxy-2-alkylthiopyrimidines previously investigated by us were modified by inserting a methyl group on their ether or thioether side chains. These compounds gave

Synthesis of new derivatives of 5-(3,4-dihydro-2Н-pyrrol-5-yl)-pyrimidine

Gasparyan,Alexanyan,Arutyunyan,Kocharov,Martirosyan,Tamazyan,Ayvazyan,Panosyan,Danagulyan

, p. 1646 - 1653 (2017/01/28)

By one-stage condensation of 6-(arylamino)pyrimidine-2,4(1Н,3Н)-diones with pyrrolidin-2-one new potential antiviral compounds were obtained, analogs of pyrrolinylpyrimidine containing structural fragments of known drugs AZT and HEPT used in treating HIV-infections.

Enantiomeric 4-Acylamino-6-alkyloxy-2 Alkylthiopyrimidines As Potential A3Adenosine Receptor Antagonists: HPLC Chiral Resolution and Absolute Configuration Assignment by a Full Set of Chiroptical Spectroscopy

Rossi, Daniela,Nasti, Rita,Marra, Annamaria,Meneghini, Silvia,Mazzeo, Giuseppe,Longhi, Giovanna,Memo, Maurizio,Cosimelli, Barbara,Greco, Giovanni,Novellino, Ettore,Da Settimo, Federico,Martini, Claudia,Taliani, Sabrina,Abbate, Sergio,Collina, Simona

, p. 434 - 440 (2017/02/10)

The chiral separation of enantiomeric couples of three potential A3adenosine receptor antagonists: (R/S)-N-(6-(1-phenylethoxy)-2-(propylthio)pyrimidin-4-yl)acetamide (1), (R/S)-N-(2-(1-phenylethylthio)-6-propoxypyrimidin-4-yl)acetamide (2), and

New approach to synthesize symmetrical and unsymmetrical 6-(N-Alkyl(Aryl)amino)-and 6-(N, N-dialkyl(Aryl)amino)-2,4-bis(Alkyl(Aryl)Thio) pyrimidines as anti-platelet agents

Liu, Guocheng,Xu, Jiaxi,Yu, Mingwu,Chen, Ning,Zhang, Si,Ding, Zhongren,Du, Hongguang

scheme or table, p. 650 - 659 (2012/06/01)

A new and straightforward procedure has been developed for the preparation of symmetrical and unsymmetrical 6-(N-alkyl(aryl)amino)-and 6-(N,N- bisalkyl(aryl)amino)-2,4-bis(alkyl(aryl)thio)pyrimidines. The two identical or different alkylthio groups were s

Novel synthesis approach and antiplatelet activity evaluation of 6-alkylamino-2,4-dialkyl(aryl)thiopyrimidines

Liu, Guocheng,Xu, Jiaxi,Park, Ki Chul,Chen, Ning,Zhang, Si,Ding, Zhongren,Wang, Feng,Du, Hongguang

experimental part, p. 5156 - 5161 (2011/07/31)

A new and efficient procedure has been designed for the preparation of 6-alkylamino-2,4-dialkyl(aryl)thiopyrimidines. The first alkylthio group was introduced into the pyrimidine ring by S-alkylation. The introduction of the second one was successfully ac

Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists

Cosimelli, Barbara,Greco, Giovanni,Ehlardo, Marina,Novellino, Ettore,Da Settimo, Federico,Taliani, Sabrina,La Motta, Concettina,Bellandi, Marusca,Tuccinardi, Tiziano,Martinelli, Adriano,Ciampi, Osele,Trincavelli, Maria Letizia,Martini, Claudia

, p. 1764 - 1770 (2008/12/22)

A number of derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine (5) were synthesized and biologically evaluated as A3 adenosine receptor (A3 AR) antagonists. The new compounds were designed as open chain analogues of a triazolopyrimidinone derivative displaying submicromolar affinity for the A3 AR, which had been previously identified using a 3D database search. Substituents R, R′, and R″ attached to the parent compound 5 were chosen according to factorial design and stepwise lead optimization approaches, taking into account the essentially hydrophobic nature of the A3 AR binding site. As a result, 5m (R = n-C3H 7, R′ = 4-ClC6H4CH2, R″ = CH3) was identified among the pyrimidine derivatives as the ligand featuring the best combination of potency and selectivity for the target receptor. This compound binds to the A3 AR with a Ki of 3.5 nM and is devoid of appreciable affinity for the A1, A 2A, and A2B ARs.

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