29171-45-7

Upstream product

• 434300-91-1 ethyl 2-(4-ethynylphenoxy)acetate 
• 178321-69-2 ethyl 2-(4-(2-(trimethylsilyl)ethynyl)phenoxy)acetate 
• 2200-91-1 4-ethynylphenol 

Downstream Products

• 1220716-11-9 C₁₇H₁₄O₃ 
• 1242177-76-9 N-[3-(3-benzyloxybenzoyl)phenyl]-2-(4-ethynylphenoxy)acetamide 
• 1242177-75-8 N-[3-(4-benzyloxybenzoyl)phenyl]-2-(4-ethynylphenoxy)acetamide 
• 1242177-77-0 N-(3-benzoylphenyl)-2-(4-ethynylphenoxy)acetamide 
• 29171-52-6 [4-(5-morpholin-4-yl-penta-1,3-diynyl)-phenoxy]-acetic acid 

Relevant academic research and scientific papers

INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY

The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.

Discovery of carboranes as inducers of 20S proteasome activity

(Chemical Equation Presented) The carborane framework gives analogues able to induce 20S proteasome activities. A series of ortho-carboranylphenoxy derivatives were synthesized as 20S proteasome agonists, and carborane derivatives 11 a and 11 b were found

Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1α inhibitors

A series of boron-containing phenoxyacetanilide derivatives 8a-f, 9a-f, 15, and 16 were synthesized as hypoxia-inducible factor (HIF)-1α inhibitors. Among the compounds synthesized, carboranylphenoxyacetanilide 16 (GN26361) was found to be a potent inhibitor against HIF-1α accumulation under hypoxic conditions and inhibited the hypoxia-induced HIF-1 transcriptional activity in HeLa cells (IC50 = 0.74 μM). Compound 16 suppressed hypoxia-induced HIF-1α accumulation and vascular endothelial growth factor mRNA expression in a concentration-dependent manner without affecting the expression of HIF-1α mRNA.

Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA1/GPR40), a potential target for the treatment of type II diabetes

A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid receptor 1 (FFA1) has been discovered and explored. The preferred compound 20 (TUG-424, EC50 = 32 nM) significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity.