291744-03-1

Basic information

• Product Name: 5-chloro-2-(phenylethynyl)pyridine
• Synonyms: 5-chloro-2-(phenylethynyl)pyridine
• CAS NO: 291744-03-1
• Molecular Weight: 213.666
• Mol File: 291744-03-1.mol

Chemical Properties

• CAS DataBase Reference: 5-chloro-2-(phenylethynyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-(phenylethynyl)pyridine(291744-03-1)
• EPA Substance Registry System: 5-chloro-2-(phenylethynyl)pyridine(291744-03-1)

Safety Data

• Hazardous Substances Data: 291744-03-1(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 244221-57-6 5-chloro-2-iodo-pyridine 

Relevant articles and documents

Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation

Pd-catalysed C-C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Herein, we describe the scope and limitations of an alternative to DMF derived from renewable sources (Cyrene) in Sonogashira cross-coupling and Cacchi-type annulations.

Pyrazolopyridines

The invention provides the compounds of formula (I) wherein: R0and R1are independently selected from H, halogen, C1-6alkyl, C1-6alkoxy, or C1-6alkoxy substituted by one or more fluorine atoms; R2