291748-20-4Relevant academic research and scientific papers
NEW DIAZOLE DERIVATIVES AS SEROTONERGIC AGENTS
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Page 12, (2008/06/13)
The present invention provides compounds of general formula (1) wherein: two atoms of X, Y, or Z are nitrogen and the third atom is sulfur or oxygen; R is H, halogen, OH, SH, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, phenoxy, thiophenoxy, phenyl or substituted phenyl; A is C, CH, or N; R1 is aryl, heteroaryl, or cycloalkyl groups, optionally substituted by from 1 to 3 substituents selected from C1-C6 alkyl, C1-C6 alkoxy; CF3, Cl, Br, F, CN, or CO2CH3; R2 is H or alkyl; R3 is C1-C6 alkyl, optionally substituted aryl, optionally substituted 5- or 6-membered heteroaryl, C3 to C8 cycloalkyl optionally substituted by C1-C6 alkyl, or a 3 to 8-membered heterocyclic ring containing one or more heteroatoms selected from O, S or N; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods of treating central nervous system disorders using these compounds.
1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors
Sabb, Annmarie L,Vogel, Robert L,Kelly, Michael G,Palmer, Yvette,Smith, Deborah L,Andree, Terrance H,Schechter, Lee E
, p. 1069 - 1071 (2007/10/03)
Amino acid derivatives of 1,2,5-thiadiazol-3-yl-piperazine related to (+)-WAY-100135 and WAY-100635 are potent 5-HT1A receptor agonists and antagonists, which have selective affinity for 5-HT1A receptors versus α and dopamine (D2, D3, and D4) receptors.
