29175-53-9

Basic information

• Product Name: 1-(2-methoxybenzyl)piperidine
• Synonyms: piperidine, 1-[(2-methoxyphenyl)methyl]-
• CAS NO: 29175-53-9
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.2961
• Mol File: 29175-53-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 281.2°C at 760 mmHg
• Flash Point: 82.7°C
• Density: 1.027g/cm³
• Vapor Pressure: 0.00361mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 1-(2-methoxybenzyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-methoxybenzyl)piperidine(29175-53-9)
• EPA Substance Registry System: 1-(2-methoxybenzyl)piperidine(29175-53-9)

Safety Data

• Hazardous Substances Data: 29175-53-9(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 7035-02-1 o-Methoxybenzyl chloride 
• 612-16-8 (2-methoxyphenyl)methanol 
• 61578-10-7 (2-methoxy-phenyl)-(piperidin-1-yl)methanone 
• 880-09-1 di(N-piperidinyl)methane 
• 20276-55-5 N-methylenepiperidinium chloride 
• 86487-17-4 2-tri-n-butylstannylanisole 
• 135-02-4 ortho-anisaldehyde 

Downstream Products

• 4764-13-0 2-(N-piperidinylmethyl)phenol 

Relevant articles and documents

Palladium(ii)-catalysed ortho-arylation of N-benzylpiperidines

PdII-catalysed ortho-arylation of benzylic heterocycles with arylboronic acid pinacol esters (Ar-BPin) via directed C-H bond activation to generate the desired biaryl products is reported. This methodology is efficient and applicable to a wide range of functionalised Ar-BPin and benzylic heterocycles, allowing the direct synthesis of important biaryl motifs in modest to good yield. This journal is

A convenient and general reduction of amides to amines with low-valent titanium

Low-valent titanium readily prepared in situ from TiCl4 and Mg powder in THF is found to be an active agent for the reduction of amides which were previously considered to be inert towards low-valent titanium. The reaction proceeds under very mild conditions, and is applicable to all types of amides, primary, secondary and tertiary, to produce the corresponding amines in good to excellent yields. This new finding provides a practical, convenient and general method for the important transformation of amides to amines. A plausible reaction mechanism is proposed.

MANNICH REACTIONS OF ARYL-TRIALKYLSTANNANES USING PREFORMED DIALKYL-METHYLENEIMINIUM SALTS

Dialkyl-methyleneiminium salts react with aryl-tributyl- and aryl-trimethylstannanes to afford the corresponding N,N-dialkylaminomethyl- derivatives in good yields.The method can be used to obtain isomers that are not obtained by classical procedures.