291753-12-3

Upstream product

• 131118-61-1 3'-tert-butyldimethylsilylthymidine 5'-carboxaldehyde 
• 79722-21-7 tert-butyl N-(benzyloxy)carbamate 
• 291753-10-1 4-benzyloxy-1-[4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one 
• 291753-09-8 4-benzyloxy-1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidin-2-one 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 380615-25-8 3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-carbaldehyde O-benzyl-oxime 
• 291753-11-2 C₃₅H₄₉N₃O₇Si 

Downstream Products

• 380615-26-9 C₅₆H₆₇N₅O₁₂Si 
• 380615-27-0 N-benzyloxy-2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-acetamide 
• 291753-13-4 C₅₅H₆₅N₅O₁₃Si 

Relevant academic research and scientific papers

Synthesis and biophysical studies of oligonucleotides containing hydroxamate linkages

Novel thymidine dimers containing hydroxamate linkages were synthesized, incorporated into oligonucleotide sequences and studied their hybridization properties against complementary DNA and RNA targets.

Syntheses and binding studies of oligonucleotides containing N- hydroxycarbamate linkages: Potential DNA cleaving antisense oligomers

An efficient synthesis of N-hydroxycarbamate containing thymidine dimer 9 was accomplished and it was incorporated into automatic DNA syntheses to make thymidine 16mers T*-1, T*-2 and T*-3. Binding abilities of T*-1, T*-2 and T*-3 with poly (dA)-16mer were assayed by melting denaturation (Tm) studies of the corresponding duplexes. Iron binding ability of a thymidine oligomer with N-hydroxycarbamate linkages was studied by MALDI-MS. Nuclease stability assays showed that the modified oligonucleotides have enhanced resistance toward nuclease S1 (endonuclease) compared to natural oligonucleotides. (C) 2000 Elsevier Science Ltd.

Synthesis and biophysical studies of oligonucleotides containing hydroxamate linkages

Novel oligonucleotide dimers containing hydroxamate linkages (15 and 16) were synthesized, incorporated into oligonucleotide sequences and studied for their hybridization properties with complementary DNA and RNA targets. The modified oligonucleotides showed similar binding properties and enhanced resistance to exonucleases compared to natural oligonucleotides. (C) 2000 Elsevier Science Ltd.