29176-45-2

Upstream product

• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 

Downstream Products

• 197807-71-9 2-[N-(tert-butoxycarbonylmethyl)-N-(N'-{m-[2-(triphenylmethyl)tetrazol-5-ylmethyloxy]phenyl}ureidomethylcarbonyl)amino]benzophenone 
• 197807-70-8 2-[N-(tert-butoxycarbonylmethyl)-N-(N'-{m-[2-(triphenylmethyl)tetrazol-5-yl]phenyl}ureidomethylcarbonyl)amino]benzophenone 
• 171724-17-7 2-(N-(tert-butoxycarbonylmethyl)-N-{N'-[m-(2-propenyloxycarbonylmethylthio)phenyl]ureidomethylcarbonyl}amino)benzophenone 
• 171724-16-6 2-(N-(tert-butoxycarbonylmethyl)-N-{N'-[m-(2-propenyloxycarbonylmethyloxy)phenyl]ureidomethylcarbonyl}amino)benzophenone 
• 171724-15-5 2-(N-(tert-butoxycarbonylmethyl)-N-{N'-[m-(2-propenyloxycarbonylmethyl)phenyl]ureidomethylcarbonyl}amino)benzophenone 
• 197807-61-7 [3-({(2-Benzoyl-phenyl)-[2-(3-m-tolyl-ureido)-acetyl]-amino}-methyl)-phenyl]-carbamic acid tert-butyl ester 
• 171724-76-8 2-(N-(tert-butylcarbamoylmethyl)-N-{N'-[m-(2-propenyloxycarbonyl)phenyl]ureidomethylcarbonyl}amino)benzophenone 
• 171724-14-4 2-(N-(tert-butoxycarbonylmethyl)-N-{N'-[m-(2-propenyloxycarbonyl)phenyl]ureidomethylcarbonyl}amino)benzophenone 

Relevant academic research and scientific papers

Synthesis and pharmacological properties of ureidomethylcarbamoylphenylketone derivatives. A new potent and subtype-selective nonpeptide CCK-B/gastrin receptor antagonist, S-0509

A novel series of CCK-B/gastrin receptor antagonists - ureidomethylcarbamoylphenylketone derivatives - were designed, synthesized, and evaluated for activity. Structure-activity relationship studies revealed the importance of a carboxylic acid at substituent R2 and a tert-butoxycarbonyl group at R1 in structure A. Compound 7a (S-0509) showed remarkable affinity for the CCK-B/gastrin receptor and a subtype selectivity profile in vitro. Administration (id) of 7a led to excellent inhibition of gastric acid secretion induced by pentagastrin in anesthetized rats with an ED50 value of 0.014 mg/kg. Furthermore, 7a proved to have poor blood-brain permeability by its small effect on enhancement of morphine analgesia. Thus, S-0509 has an increase in selectivity for the peripheral effects of gastrin antagonism from the central effects of CCK-B antagonism.