292036-87-4Relevant academic research and scientific papers
9-Benzylpurines with inhibitory activity against Mycobacterium tuberculosis
Bakkestuen, Anne Kristin,Gundersen, Lise-Lotte,Langli, Geir,Liu, Fusheng,Nolsoe, Jens M.J.
, p. 1207 - 1210 (2000)
9-Benzylpurines with a variety of substituents in the 2-, 6- and/or 8-position have been prepared and screened for antimycobacterial effects. High inhibitory activity against Mycobacterium tuberculosis was found for 9-benzylpurines carrying a phenylethynyl-, trans-styryl or aryl substituents in the 6-position and generally chlorine in the 2-position tends to increase activity. (C) 2000 Elsevier Science Ltd. All rights reserved.
Synthesis of (E)-6-alkenylpurines via Pd-catalyzed stannation/ protodestannation tandem process of alkynylpurines
Klecka, Martin,KovacEK, Martin,Tobrman, Toma,Dvoak, Dalimil
experimental part, p. 313 - 332 (2010/08/05)
A methodology for the synthesis of (E)-6-alkenylpurines, starting from 6-iodopurines, based on a Pd-catalyzed stannation/protodestannation protocol, is described. The alkynylation reactions were catalyzed by Pd(OAc) 2/PPh3 in acetonitrile. The Pd-catalyzed stannation itself provided a mixture of Z regioisomers but following protodestannation using TFA induces Z to E isomerization giving (E)-6-alkenylpurines. The reactivity of other 2-and 8-alkynyl purines has also been studied.
Covalent analogues of DNA base-pairs and triplets IV+. Synthesis of trisubstituted benzenes bearing purine and/or pyrimidine rings by cyclotrimerization of 6-ethynylpurines and/or 5-ethynyl-1,3-dimethyluracil
Hocek, Michal,Stara, Irena G.,Stary, Ivo,Dvorakova, Hana
, p. 1223 - 1235 (2007/10/03)
Ni-Catalyzed cyclotrimerizations of 6-ethynylpurines 3 or 5-ethynyl-1,3-dimethyluracil (4) afforded the 1,2,4-tris(purin-6-yl)benzenes 7 or 1,2,4-tris(1,3-dimetyhyluracil-5-yl)benzene (9), respectively. The symmetrical 1,3,5-tris(purin-6-yl)benzenes 8 wer
