29204-77-1Relevant academic research and scientific papers
GPR103 protein receptor inhibitor as well as preparation and application thereof
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Paragraph 0084; 0088, (2021/06/06)
The invention provides a GPR103 protein receptor inhibitor as well as preparation and application thereof, and particularly provides a compound shown as a formula I or pharmaceutically acceptable salt thereof. The compound has excellent GPR103 protein inhibitory activity.
A highly facile and efficient one-step synthesis of N6-adenosine and N6-2′-deoxyadenosine derivatives
Wan, Zhao-Kui,Binnun, Eva,Wilson, Douglas P.,Lee, Jinbo
, p. 5877 - 5880 (2007/10/03)
(Chemical Equation Presented) A highly facile and efficient one-step synthesis of N6-adenosine and N6-2′-deoxyadenosine derivatives has been developed. Treatment of inosine or 2′-deoxyinosine, without protection of sugar hydroxyl groups, with alkyl or arylamines, in the presence of BOP and DIPEA in DMF, led to the formation of N6- adenosine and N6-2′-deoxyadenosine derivatives in good to excellent yields. Carcinogenic polyaromatic hydrocarbon (PAH) N 6-2′-deoxyadenosine adduct 10 and a rare DNA constituent 11 were thus synthesized directly from 2′-deoxyinosine both in 98% yield.
