292077-58-8

Basic information

• Product Name: 1-(2-BROMOQUINOLIN-3-YL)METHANAMINE
• Synonyms: 1-(2-BROMOQUINOLIN-3-YL)METHANAMINE;(2-BroMoquinolin-3-yl)MethanaMine
• CAS NO: 292077-58-8
• Molecular Formula: C₁₀H₉BrN₂
• Molecular Weight: 237.1
• Mol File: 292077-58-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2-BROMOQUINOLIN-3-YL)METHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-BROMOQUINOLIN-3-YL)METHANAMINE(292077-58-8)
• EPA Substance Registry System: 1-(2-BROMOQUINOLIN-3-YL)METHANAMINE(292077-58-8)

Safety Data

• Hazardous Substances Data: 292077-58-8(Hazardous Substances Data)

Usage

General Description

1-(2-Bromoquinolin-3-yl)methanamine is a chemical compound with the molecular formula C10H8BrN2. It belongs to the class of organic compounds known as quinoline carboxamides. 1-(2-BROMOQUINOLIN-3-YL)METHANAMINE is a derivative of quinoline, a heterocyclic aromatic compound consisting of a benzene ring fused to a pyridine ring. The presence of a bromine atom at position 2 of the quinoline ring and a methanamine group attached to position 1 make this compound valuable for research and drug development. The presence of the quinoline backbone in this compound suggests its potential use in pharmaceuticals and as a building block in chemical synthesis. However, further research is needed to fully understand its applications and potential benefits in various fields.

Upstream product

• 292077-57-7 2-Bromoquinolin-3-ylmethyl azide 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 
• 35740-83-1 2-bromo-3-bromomethylquinoline 

Downstream Products

• 406920-22-7 N-(2-bromo-quinolin-3-ylmethyl)-2-methoxy-benzamide 
• 704912-40-3 7-methoxyquinolino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one 
• 620962-73-4 N-(2-bromoquinolin-3-yl)methyl-N-[2,2-bis(phenylthio)ethenyl]amine 
• 406920-23-8 N-(2-cyano-quinolin-3-ylmethyl)-2-methoxy-benzamide 
• 620962-74-5 N-(2-bromoquinolin-3-yl)methyl-N-[2,2-bis(phenylthio)ethenyl]trifluoroacetamide 
• 620962-82-5 7-(2-methyl-4-oxohex-2-enoyl)-6,8-dihydro-6-(phenylsulfinylmethyl)pyrrolo[3,4-b]quinoline 
• 620962-81-4 7-(2-methyl-4-oxohex-2-enoyl)-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline 
• 620962-77-8 7-(2-methyl-4-oxohexanoyl)-6,8-dihydro-6-(phenylsulfinylmethyl)pyrrolo[3,4-b]quinoline 
• 620962-76-7 7-(2-methyl-4-oxohexanoyl)-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline 
• 620962-75-6 7-trifluoroacetyl-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline 
• 55854-89-2 8-methyl-7-propionylindolizino[1,2-b]quinoline-9(11H)-one 

Relevant articles and documents

New Pyridone Approach: Total Synthesis of Mappicine Ketone (Nothapodytine B)

A novel synthesis of mappicine ketone, which possesses strong selective activity against the herpes viruses HSV-1 and HSV-2, including those Acyclovir-resistant, and human cytomegalovirus (HCMV) has been efficiently accomplished. The synthesis highlights a new pyridone approach that effectively combines a double, intramolecular Michael addition in a conjugated ester-conjugated amide with oxidation-decarboxylation of the resulting piperidone.

Total synthesis of mappicine ketone (nothapodytine B) by means of sulfur-directed 5-exo-selective aryl radical cyclization onto enamides

Enamides 5, on treatment with Bu3SnH-AIBN, underwent aryl radical cyclization in a 5-exo manner to give 1-[bis(phenylthio)methyl]dihydroisoindoles 6, which were partially desulfurized with Bu3SnH-AIBN to give 1-mono(phenylthio)methyl

Preparation of camptothecin and of its derivatives

The present invention relates to a novel process for preparation of camptothecin and of its derivatives by convergent synthesis starting from a 3-(aminomethyl)quinoline derivative and 5-hydroxy-5-ethyl-6-oxo-5,6-dihydropyrancarboxylic acid and to the intermediates obtained.