29209-30-1

Basic information

• Product Name: methyl 3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
• Synonyms: methyl 3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide;3,4-Dihydro-2-methyl-3-methoxycarbonyl-4-oxo-2H-1,2-benzothiazine 1,1-dioxide
• CAS NO: 29209-30-1
• Molecular Formula: C₁₁H₁₁NO₅S
• Molecular Weight: 269.27374
• EINECS: 249-509-1
• Mol File: 29209-30-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 433.6°Cat760mmHg
• Flash Point: 216°C
• Appearance: /
• Density: 1.432g/cm³
• Vapor Pressure: 1.02E-07mmHg at 25°C
• Refractive Index: 1.579
• PKA: 9.57±0.20(Predicted)
• CAS DataBase Reference: methyl 3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide(29209-30-1)
• EPA Substance Registry System: methyl 3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide(29209-30-1)

Safety Data

• Hazardous Substances Data: 29209-30-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H11NO5S/c1-12-9(11(14)17-2)10(13)7-5-3-4-6-8(7)18(12,15)16/h3-6,9H,1-2H3

Upstream product

• 6639-62-9 methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide 
• 67-68-5 dimethyl sulfoxide 

Relevant articles and documents

Synthetic method of piroxicam

The invention belongs to the field of chemical synthesis, and more specifically relates to a synthetic method of piroxicam. The synthetic method of piroxicam comprises following steps: 1, sodium saccharin and ethyl chloroacetate are taken as initial raw materials, and condensation reaction is carried out so as to obtain 3-oxo-1,2-benzoisothiazoline-2-methyl acetate-1,1-dioxide; 2, sodium methylateis added into the product in step 1, reaction is carried out under catalytic effect of potassium iodide, and 2-methyl-3,4- dioxo-4-oxo-2H-1,-2- benzothiazine-3-carboxylic acid methyl ester-1, 1-dioxide is obtained under the effect of DMSO; 3, the above product is reacted with 2-aminopyridine at 130 DEG C for 10h so as to obtain a high purity finished product. According to the synthetic method, potassium iodide is taken as a catalyst to increase the reaction conversion rate of step 2 obviously, impurity content is controlled effectively; and the total yield is increased to 69%.