292152-99-9

Upstream product

• 292152-97-7 (Z)-5-chloropent-4-en-2-ynyl methanesulfonate 
• 292152-98-8 (Z)-5-chloro-1-azidopent-4-en-2-yne 
• 123150-64-1 (Z)-5-chloropent-4-en-2-yn-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 651733-30-1 (Z)-5-chloro-1-aminopent-4-en-2-yne 

Downstream Products

• 292153-02-7 (Z)-1-methylsulfonyloxy-8-(4-methylphenylsulfonamido)oct-4-ene-2,6-diyne 
• 292153-01-6 (Z)-1-hydroxy-8-(4-methylphenylsulfonamido)oct-4-ene-2,6-diyne 
• 292153-00-5 (Z)-1-tert-butyldimethylsilyloxy-8-(4-methylphenylsulfonamido)oct-4-ene-2,6-diyne 

Relevant academic research and scientific papers

Nitrogen substituted cyclic enediynes: Synthesis, thermal reactivity and coniplexation with metal ions

A number of N-substituted cyclic enediynes (azaenediynes) have been synthesized via Pd(0)-catalysed ene-yne coupling followed by N-alkylation. The simplest of them, a 10-membered monocyclic enediyrie 1, underwent Bergman cyclization (BC) at 23°C with a half-life of 72 h. The kinetics of BC slowed down considerably by fusing a benzene ring onto the enediyne. Several novel bis(azaenediyne)s and bis(diazaenediyne)s 3-6 have been synthesized. Their onset temperatures for BC were lowered under metal ion complexation conditions. The Royal Society of Chemistry 2000.