292164-75-1Relevant academic research and scientific papers
Palladium-catalyzed arylation of N,N-dialkylhydrazines and the subsequent conversion to anilines
Liu, Xiaoxiang,Barry, Michael,Tsou, Hwei-Ru
, p. 8409 - 8412 (2007)
Palladium-catalyzed aminations of different ArBr with N,N-dialkylhydrazines are described. The reaction proceeded in moderate to excellent yield (up to 90%) with good functional groups compatibilities as cyano, ester, ketone and Boc-amine groups are all well tolerated. Several hydrazines were proved to be good coupling partners and this process provided a general method for the isosteric replacement of benzyl amines with arylhydrazines. Moreover, a method for the N-N bond cleavage of arylhydrazines was discovered, and this two-step sequence could be employed as an alternative synthesis of aniline derivatives.
