29228-93-1

Usage

InChI:InChI=1/C22H30N4/c1-5-25(6-2)21-13-9-19(10-14-21)17-23-24-18-20-11-15-22(16-12-20)26(7-3)8-4/h9-18H,5-8H2,1-4H3/b23-17+,24-18+

Upstream product

• 120-21-8 4-Diethylaminobenzaldehyde 
• 18300-47-5 4-diethylamino-benzaldehyde-semicarbazone 

Relevant academic research and scientific papers

Azine based AIEgens with multi-stimuli response towards picric acid

Multifunctional aggregation induced emission luminogens (AIEgens) are novel materials which have significant applications in various fields including biomedical, optoelectronics and sensors. Enormous efforts have been directed towards the strategic development and characterisation of AIEgens, in order to better understand the AIE mechanism. Herein, we studied the photophysical properties of symmetrical azine (D-π-D) based AIEgens in detail by varying the solvent polarity and viscosity. The AIE behaviour of the azine derivatives relies on the substituents on the nitrogen atom of the amine moiety. Further, these azine derivatives sense the picric acid (PA) with high selectivity and sensitivity in both monomer and aggregated forms. The hydrogen bonding interaction of PA with any one side of the amine nitrogen leads to the formation of a new intramolecular charge transfer state which results in the formation of new absorption and emission spectra. Interestingly in the presence of PA, azine monomers exhibit fluorescence enhancement in pure THF, while aggregated azine molecules show fluorescence quenching in THF-water mixtures.

Dihydrazone compound high in affinity with Abeta protein and Tau protein, derivative thereof, and applications of dihydrazone compound and derivative

The invention provides a dihydrazone compound high in affinity with Abeta protein and Tau protein, a derivative thereof, and applications of the dihydrazone compound and the derivative. The structureof the dihydrazone compound is represented by formula I. The dihydrazone compound can be directly taken as a fluorescence probe used for detecting neurofibrillary tangles in vivo or in tissue samples;when the dihydrazone compound is adopted in nuclear medicine imaging, appropriate radioisotopes are needed for labeling. The dihydrazone compound is especially suitable to be used for diagnosis of neurodegenerative diseases, and diagnosis of patients with diseases with Abeta plaques including Alzheimer's disease.

Compound capable of detecting organophosphate neurotoxic agent stimulants and application thereof

The invention relates to a compound capable of detecting an organophosphate neurotoxic agent stimulants and application thereof. The compound has a structural general formula shown as the specification, can be used for detection of organophosphate neurotoxic agent stimulants according to the change of color or fluorescence in preparation of solutions, films or test paper. The compound provided by the invention has the advantages of simple preparation method, high yield, easy separation, high purity, and sensitive response to organophosphorus neurotoxic agents, and can achieve quick and accurate detection of organophosphorus neurotoxic agent stimulants in solutions or gas phases.

Thermolysis of semicarbazones to the corresponding azines through reactive N-substituted isocyanate intermediates

Thermolysis of semicarbazones (I) to azines (II) occurs through reactive N-substituted isocyanate intermediates (Ia) which can be converted in situ to carbamates and N-substituted ureas.