29236-11-1

Upstream product

• 108-31-6 maleic anhydride 
• 100-01-6 4-nitro-aniline 
• 36342-10-6 (Z)-3-(4-nitro-phenylcarbamoyl)-acrylic acid 
• 4338-06-1 N-(4-nitrophenyl)maleimide 
• 1122-17-4 dichloromaleic acid anhydride 

Downstream Products

• 1109273-53-1 2-(4-nitrophenyl)-pyrrolo[3,4-b][1,4]benzoxazine-1,3(2H,9H)-dione 
• 1109273-76-8 2-(4-nitrophenyl)-7-tert-butyl-pyrrolo[3,4-b][1,4]benzoxazine-1,3(2H,9H)-dione 
• 1109273-65-5 2-(4-nitrophenyl)-7-chloro-pyrrolo[3,4-b][1,4]benzoxazine-1,3(2H,9H)-dione 
• 1449434-81-4 C₁₈H₁₀ClN₃O₄ 
• 1186082-70-1 2,3-dichloro-N-(4-nitrophenyl)bicyclo[2.2.2]oct-5-ene-2,3-dicarboximide 
• 958732-35-9 C₂₂H₁₉ClN₄O₆ 
• 958732-36-0 C₂₁H₁₉ClN₄O₅ 
• 1258283-39-4 C₂₃H₂₁ClN₄O₄ 
• 958732-32-6 C₁₂H₁₀ClN₃O₄ 
• 958732-55-3 C₁₅H₁₅ClN₄O₄ 
• 958729-49-2 C₁₅H₁₅ClN₄O₄ 
• 958732-52-0 C₂₁H₁₉ClN₄O₅ 
• 958729-50-5 C₁₈H₁₅ClN₆O₄ 
• 459212-29-4 C₂₁H₁₉ClN₄O₄ 

Relevant academic research and scientific papers

Color Tuning of the Aggregation-Induced Emission of Maleimide Dyes by Molecular Design and Morphology Control

Aggregation-induced emission (AIE)-active maleimide dyes, namely, 2-p-toluidino-N-p-tolylmaleimide, 3-phenyl-2-toluidino-N-p-tolylmaleimide, 2-p-thiocresyl-3-p-toluidino-N-p-tolylmaleimide, and 2,3-dithiocresyl-N-arylmaleimides, were synthesized by facile

Synthesis and biological evaluation of 3-chloro-4-(indol-3-yl)-2,5- pyrroledione derivatives as antitumor agents

A series of 3-chloro-4-(indol-3-yl)-2,5-pyrroledione derivatives were synthesized and evaluated for their cytotoxic activities in vitro against five human cancer cell lines (K562, A549, ECA-109, KB and SMMC-7721). Most compounds displayed potent cytotoxicity with IC50 values in low micromolar range. The results showed that the existence of the chlorine atom at 3-position on the pyrroledione ring was crucial for the activity. Compound 6a, the most potent one (IC50: 0.67～3.93 μM), would be a promising template for further development of novel antitumor agents.

Inhibition of Bfl-1 with N-aryl maleimides

High-throughput screening of 66,000 compounds using competitive binding of peptides comprising the BH3 domain to anti-apoptotic Bfl-1 led to the identification of 14 validated 'hits' as inhibitors of Bfl-1. N-Aryl maleimide 1 was among the validated 'hits'. A chemical library encompassing over 280 analogs of 1 was prepared following a two-step synthesis. Structure-activity studies for inhibition of Bfl-1 by analogs of N-aryl maleimide 1 revealed a preference for electron-withdrawing substituents in the N-aryl ring and hydrophilic amines appended to the maleimide core. Inhibitors of Bfl-1 are potential development candidates for anti-cancer therapeutics.

Synthesis of novel 1,4-benzoxazine-2,3-dicarboximides from maleic anhydride and substituted aromatic amines

A series of novel 1,4-benzoxazine-2,3-dicarboximides starting from maleic anhydride and substituted aromatic amines were synthesized. Copyright Taylor & Francis Group, LLC.

Synthesis and characterization of new compounds containing 1,4-dithiintetracarboxydiimide units

New compounds containing 1,4-dithiintetracarboxydiimide units were synthesized by the disubstitution reaction of N-substituted 2,3- dichloromaleimide with sodium sulflde nonahydrate or thiourea. IR, UV-vis and 1H-NMR spectroscopy, as well as elemental analysis, confirmed their structures. Thermal conversion of 1,4-dithiine ring to thiophene was monitored by differential calorimetry (DSC) and thermogravimetric (TGA) measurements.

Syntheses and structures of N-phenylmaleimidetriazoles and by-products

The syntheses, properties, and structures of N-phenylmaleimidetriazole derivatives are described. Intermediates and by-products are also discussed. 1b. a = 43.997(7) A, 5.7610(9) A, 8.245(1) A, β = 99.339(4)°, C2/c; 2a. a = 13.646(4) A, b = 7.7

Generality and scope of the synthesis of 2-arylpyrrolo[3,4-b] quinoxaline-1,3-diones from 2,3-dichloro-N-arylmaleimides. II

Nucleophilic substitution of 2,3-dichloro-N-arylmaleimides (1) and (2) with a series of arylamines gives 2-arylamino-3-chloro-N-arylmaleimides (3) and (4), respectively. When 4 is treated with sodium azide at room temperature, it cyclizes to the 2-(p-methoxyphenyl)pyrrolo[3,4-b]quinoxaline- 1,3-diones (5). Under the same conditions, the 2-(p-nitrophenyl) analogue (3) fails to cyclize. Ring closure is also subject to the steric and electronic effects of substituents in the nucleophile.