2924-15-4

Basic information

• Product Name: 2-Fluorophenylhydrazine hydrochloride
• Synonyms: 1-(2-FLUOROPHENYL)HYDRAZINE HYDROCHLORIDE;2-FLUOROPHENYLHYDRAZINE HCL;2-FLUOROPHENYLHYDRAZINE HYDROCHLORIDE;O-FLUOROPHENYLHYDRAZINE HYDROCHLORIDE;2-FluorophenylhydrazineHydrochloride/O-FluorophenylhydrazineHydrochloride;2-FLUOR PHENYL HYDRAZINE HYDROCHLORIDE;2-Fluorophenylhydrazine hydrochloride 97%;2-Fluorophenylhydrazinehydrochloride97%
• CAS NO: 2924-15-4
• Molecular Formula: C₆H₇FN₂*ClH
• Molecular Weight: 162.59
• EINECS: 220-885-9
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Phenylhydrazine;Hydrazines;Nitrogen Compounds;Organic Building Blocks;amine| alkyl Fluorine
• Mol File: 2924-15-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 200-205 °C (dec.)(lit.)
• Boiling Point: 211.5 °C at 760 mmHg
• Flash Point: 205°C
• Appearance: white to light yellow crystal powder
• Density: 1.257g/cm3
• Vapor Pressure: 0.182mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• BRN: 3627985
• CAS DataBase Reference: 2-Fluorophenylhydrazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluorophenylhydrazine hydrochloride(2924-15-4)
• EPA Substance Registry System: 2-Fluorophenylhydrazine hydrochloride(2924-15-4)

Safety Data

• Hazard Codes: Xn,Xi,T
• Statements: 20/21/22-36/37/38-43-40-23/24/25
• Safety Statements: 26-37/39-36/37/39-45-36/37-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 2924-15-4(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Uses

2-Fluorophenylhydrazine hydrochloride was used in the preparation of pyrazole derivatives.

InChI:InChI=1/C6H7FN2.ClH/c7-5-3-1-2-4-6(5)9-8;/h1-4,9H,8H2;1H

Upstream product

• 348-54-9 2-Fluoroaniline 

Downstream Products

• 103286-26-6 2-(o-fluorophenyl)-1(2H)-phthalazinone 
• 700806-04-8 N₃-[4-(3-diethylamino-propoxy)-3,5-dimethoxy-phenyl]-1-(2-fluorophenyl)-1H-[1,2,4]triazole-3,5-diamine 
• 348-15-2 benzaldehyde-(2-fluoro-phenylhydrazone) 
• 912963-98-5 adamantane-1-carboxylic acid N'-(2-fluorophenyl)hydrazide 
• 76255-89-5 8-fluoro-1-keto-1,2,3,4-tetrahydrocarbazole 
• 1358761-74-6 C₁₃H₉BrF₂N₂O 
• 1358761-75-7 2-chloro-5-fluorobenzoic acid N'-2-fluorophenylhydrazide 
• 888952-52-1 5-fluoro-1-(2-fluorophenyl)-2,3-dihydro-1H-indazol-3-one 
• 1318785-88-4 C₂₀H₁₇F₂N₃O₄ 
• 1318786-50-3 C₁₉H₁₆FN₃O₄ 
• 1318785-08-8 (S)-3-{[1-(2-fluoro-phenyl)-5-hydroxy-1H-pyrazole-3-carbonyl]-amino}-3-m-tolyl-propionic acid 
• 1279038-74-2 C₂₂H₂₂FN₃O₄ 
• 1318785-90-8 (S)-3-{[1-(2-fluorophenyl)-5-hydroxy-1H-pyrazole-3-carbonyl]amino}-3-p-tolylpropionic acid 
• 1318782-28-3 (S)-3-{[1-(2-fluorophenyl)-5-hydroxy-1H-pyrazole-3-carbonyl]amino}-3-(2-methoxyphenyl)propionic acid 

Relevant articles and documents

Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents

A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model.

Synthesis and antimicrobial activities of novel 1H-dibenzo[a,c]carbazoles from dehydroabietic acid

A series of novel 1H-dibenzo[a,c]carbazole derivatives were synthesized in good yield through reaction of methyl 7-oxo-dehydroabietate with a variety of substituted phenylhydrazines. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, MS spectral studies and elemental analysis. All compounds were investigated for their activity against four bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas fluorescens) and three fungi (Trichophyton rubrum, Candida albicans and Aspergillus niger). Among the compound tested, 6d, 6e, 6f and 6m exhibited pronounced antibacterial activities and 6e and 6m also showed moderate antifungal activities. Particularly, 6d exhibited stronger antibacterial activity against B. subtilis comparable to positive control.