292605-22-2

Basic information

• Product Name: 2,5-dihydro-3'-phenylspiroisoxazolino-[5',5]furan-2-one
• Synonyms: 2,5-dihydro-3'-phenylspiroisoxazolino-[5',5]furan-2-one
• CAS NO: 292605-22-2
• Molecular Weight: 215.208
• Mol File: 292605-22-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,5-dihydro-3'-phenylspiroisoxazolino-[5',5]furan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dihydro-3'-phenylspiroisoxazolino-[5',5]furan-2-one(292605-22-2)
• EPA Substance Registry System: 2,5-dihydro-3'-phenylspiroisoxazolino-[5',5]furan-2-one(292605-22-2)

Safety Data

• Hazardous Substances Data: 292605-22-2(Hazardous Substances Data)

Upstream product

• 108-28-1 protoanemonin 
• 698-16-8 benzohydroximoyl chloride 

Downstream Products

• 99970-08-8 (2E)-3-[3'-phenylisoxazol-5'-yl]propenoic acid 
• 94330-95-7 3-phenyl-5-(3-phenyl-4,5-dihydroisoxazol-5-yl)isoxazole 

Relevant articles and documents

Revisiting the addition of nitriloxides on protoanemonin. A new access to (2E)-3-(3'-arylisoxazol-5'-yl)propenoic acids

Some 4-substituted arylnitriloxides undergo 1,3-dipolar cycloadditions with 5-methylene(5H)furan-2-one (protoanemonin) with formation of spiroisoxazolines. These spiroadducts can be opened to the corresponding (2E)3-(3'-arylisoxazol-5'-yl)propenoic acids 5 and 3-aryl-5[4'-(3'-aryl- 4',5'-dihydroisoxazolinyl)]isoxazole 6 by various ways, including acidic and basic treatments, as well as electrooxidation. In the latter case, the electron transfer occurs on the 4,5-dihydroisoxazolic ring and is followed by an internal dissociative electron transfer leading to the opened products.