292623-33-7Relevant academic research and scientific papers
COMPOUNDS, COMPOSITIONS AND METHODS
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, (2020/10/21)
The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, isotopically enriched analog, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or pharmaceutical composition thereof, and methods of making and using thereof.
Reactions of 2,2-dibromocyclopropyl carboxylic acids with methyllithium
Sydnes, Leiv K.,Skare, Soelvi
, p. 2073 - 2078 (2007/10/02)
For reactions of 2,2-dibromocyclopropyl carboxylic acids with methyllithium, the course reaction depends mainly on the position of the carboxyl group.When the COOH group is directly attached to the gem-dibromocyclopropane ring MeLi generally attacks the gem-dibromo moiety and gives the corresponding monobromocyclopropane as the principal product.When the reaction is performed above -80 deg C the monobromides are formed stereospecifically in the trans configuration.The highest yields, as high as 80-90percent, are obtained 0 deg C.When the carboxyl group is not directly attached to the cyclopropane ring most of the MeLi is consumed in an acid-base reaction with the COOH group.
SYNTHESIS, STRUCTURE, AND REACTIVITY OF CYCLOPROPANES AND CYCLOPROPENES. XII. PARTIAL REDUCTION OF 1,1-DIBROMO-2-METHYL-2-CYANO(METHOXYCARBONYL)CYCLOPROPANES
Latypova, M. M.,Katerinich, L. V.,Baranova, I. N.,Plemenkov, V. V.,Bolesov, I. G.
, p. 2253 - 2257 (2007/10/02)
Functional derivatives (ethers, nitriles, acids, hydrazides, and alcohols) of monohalogenocyclopropane (possible precursors of the corresponding 3,3-disubstituted cyclopropenes) were obtained by partial reduction of the gem-dibromomethylene unit with zinc in alcohol and by the necessary functional modifications in the readily obtainable 1,1-dibromo-2-methyl-2-cyano(methoxycarbonyl)cyclopropanes.The reduction of 1,1-dibromo-2-methyl-2-cyanocyclopropane is highly stereoselective and leads to an easily separated mixture of E- and Z-1-bromo-2-methyl-2-cyanocyclopropanes.
