292644-36-1

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Benzenamine, 3-(2-benzothiazolyl)-4-chloro-, serves as a crucial building block in the synthesis of pharmaceuticals and agrochemicals. Its unique structure allows for the development of new compounds with potential therapeutic and pesticidal properties.
Used in Cancer Treatment Research:
This chemical compound has been studied for its potential use in the treatment of cancer. Its specific molecular structure may contribute to the development of novel anticancer agents, targeting various types of cancer cells and potentially improving treatment outcomes.
Used as an Anti-Inflammatory Agent:
Benzenamine, 3-(2-benzothiazolyl)-4-chloro-, has also been investigated for its anti-inflammatory properties. Its potential use in the development of new anti-inflammatory drugs could provide alternative treatment options for various inflammatory conditions.
Used in Dye and Pigment Manufacturing:
In addition to its pharmaceutical applications, Benzenamine, 3-(2-benzothiazolyl)-4-chloro-, is utilized in the manufacturing of dyes and pigments. Its unique chemical structure contributes to the color and stability of these products, making it a valuable component in the dye and pigment industry.
However, it is important to handle Benzenamine, 3-(2-benzothiazolyl)-4-chloro-, with care due to its potential hazards to human health and the environment. Proper safety measures and disposal methods should be implemented to minimize any adverse effects.

Upstream product

• 54255-68-4 2-(2-chloro-5-nitrophenyl)benzo[d]thiazole 
• 137-07-5 2-amino-benzenethiol 

Downstream Products

• 353464-45-6 C₂₀H₁₁Cl₂N₃O₃S 

Relevant academic research and scientific papers

Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway

Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. In vertebrates, the hh gene encodes three different unique proteins: sonic hedgehog (Shh), desert hedgehog (Dhh) and indian hedgehog (Ihh). Disruption of the Hh signaling pathway leads to severe disorders in the development of vertebrates whereas aberrant activation of the Hh pathway has been associated with several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers. In vivo evidence suggests the antagonism of excessive Hh signaling provides a route to unique mechanism-based anti-cancer therapies. Recently the small molecule SANT-2 was identified as a potent antagonist of Hh-signaling pathway. Here, we describe the synthesis, SAR studies as well as biological evaluation of SANT-2 and its analogues. Fifteen SANT-2 derivatives were synthesized and analyzed for their interference with the expression of the Hh target gene Gli1 in a reporter gene assay. By comparison of structure and activity important molecular descriptors for Gli inhibition could be identified. Furthermore we identified derivative TC-132 that was slightly more potent than the parent compound SANT-2. Selected compounds were tested for Hh related teratogenic effects in the small teleost model medaka. Albeit Gli expression has indicated a 16-fold higher Hh-inhibiting activity than observed for the plant alkaloid cyclopamine, none of the tested compounds were able to induce the cyclopamine-specific phenotype in the medaka assay.

2-arylbenzothiazole analogues and uses thereof

The present invention relates to compounds of the general formula (I) and salts, prodrugs, and stereoisomers thereof, wherein Y independently represents S, O, NR2, SO, SO2; A independently represents a fife- or six-membered aromatic carbocycle or heterocycle and wherein R1 to R20 in formula (I) represent independently of each other a variety of different substituents comprising alkyl, aryl, aralkyl, alkylaryl, heteroaryl groups and monofunctional moieties.

2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer

The present invention relates to anticancer compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein Y independently represents S, O, NR 2 , SO, SO 2 ; A independently represents a five- or six-membered aromatic carbocycle or heterocycle and wherein R 1 in formula (I) represents one of the heteroaryl groups defined in the claims.

Solid phase combinatorial synthesis of benzothiazoles and evaluation of topoisomerase II inhibitory activity

To investigate one possible mechanism of action of the cytotoxic activity of benzothiazoles, we synthesized 2-(substituted-phenyl)benzothiazoles and evaluated their ability to inhibit topoisomerase II activities. Solid phase combinatorial method using tri