292833-07-9

Basic information

• Product Name: 4(3H)-Quinazolinone, 2-(bromomethyl)-3-(2-methoxyphenyl)-
• CAS NO: 292833-07-9
• Molecular Formula: C16H13BrN2O2
• Molecular Weight: 345.195
• Mol File: 292833-07-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4(3H)-Quinazolinone, 2-(bromomethyl)-3-(2-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 2-(bromomethyl)-3-(2-methoxyphenyl)-(292833-07-9)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 2-(bromomethyl)-3-(2-methoxyphenyl)-(292833-07-9)

Safety Data

• Hazardous Substances Data: 292833-07-9(Hazardous Substances Data)

Upstream product

• 4260-28-0 2-methyl-3-(o-methoxyphenyl)-4(3H)-quinazolinone 

Downstream Products

• 514830-32-1 3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid N'-[3-(2-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide 
• 514830-34-3 3-(4-dimethylamino-phenyl)-acrylic acid N'-[3-(2-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide 
• 514830-24-1 3-(o-methoxyphenyl)-2-acetylhydrazinomethylquinazolin-4(3H)-one 
• 514830-20-7 3-(o-methoxyphenyl)-2-hydrazinomethylquinazolin-4(3H)-one 

Relevant articles and documents

Synthesis and anti-inflammatory activity of some new 2,3-disubstituted-6-monosubstituted-quinazolin-4(3H)-ones

Some new quinazolinone derivatives, 3-(substituted phenyl)-2-(substituted phenylchalconylaminoazetidinon-2′-yl)-6-monosubstitutedquinazolin-4 (3H)-ones have been synthesized by the reaction of 3-(substituted phenyl)-2-(substituted phenylchalconylhydrazinomethyl)-6-monosubstituted-quinazolin-4(3H)-ones with acetyl chloride in the presence of triethylamine. All the compounds of this series have been evaluated for their anti-inflammatory activity against carrageenan induced oedema in albino rats. The activity of the most active member of this series i.e. 3-(o-methoxyphenyl)-2-(p-dimethylaminophenylchalconylaminoazetidinon- 2′-yl) quinazolin-4(3H)-one has been studied in detial and is compared with phenylbutazone. Interestingly this compound exhibits better anti-inflammatory activity and lower ulccrogenic liability than phenylbutazone and its toxicity is also quite low.