292835-93-9Relevant academic research and scientific papers
Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: Identification of a tetrazole-containing inhibitor with cellular activity
Liljebris, Charlotta,Larsen, Scott D.,Ogg, Derek,Palazuk, Barbara J.,Bleasdale, John E.
, p. 1785 - 1798 (2002)
Protein tyrosine phosphatases (PTPs) constitute a diverse family of enzymes that, together with protein tyrosine kinases, control the level of intracellular tyrosine phosphorylation, thus regulating many cellular functions. PTP1B negatively regulates insu
