292849-75-3Relevant academic research and scientific papers
Synthesis of cyclic dipeptides by ring-closing metathesis
Reichwein, John F.,Liskamp, Rob M. J.
, p. 2335 - 2344 (2007/10/03)
Several cyclic dipeptides (4a-g and 9a-c) have been synthesized by 'amide-to-amide' cyclization of 2a-g and 8a-c, respectively, by means of ring-closing metathesis employing the Grubbs ruthenium catalyst. The influence of additives as well as the length of the amide substituent were studied. Best yields were obtained by cyclization in solution with either lithium fluoroacetate or α,α-dichlorotoluene as an additive.
