292853-54-4Relevant academic research and scientific papers
Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation
Kaoukabi, Hanane,Kabri, Youssef,Curti, Christophe,Taourirte, Moha,Rodriguez-Ubis, Juan C.,Snoeck, Robert,Andrei, Graciela,Vanelle, Patrice,Lazrek, Hassan B.
, p. 772 - 781 (2018)
By combining the structural features of dihydropyrimidinone and 1,2,3-triazole heterocycles, novel hybrid compounds were synthesized using a simple and convenient method. A series of novel mono and bis 1,2,3-triazole was synthesized via copper-catalyzed Huisgen azide-alkyne cycloadditions (CuAAC) under microwave irradiation. The newly synthesized compounds were evaluated for their antiviral activity against varicella-zoster virus (VZV). Compounds 6aa, 7ab, 6ba and 6da showed valuable antiviral activities, with EC50 values ranging from 3.6 to 11.3 μM against TK+ and TK- VZV and without measurable cell-growth inhibition.
Regioselective chlorination at C-6 methyl position of 3,4-dihydropyrimidin- 2(1H)-ones using (dichloroiodo)benzene
Tale, Nilesh P.,Shelke, Amol V.,Bhong, Bhagyashree Y.,Karade, Nandkishor N.
, p. 981 - 986 (2013/07/26)
The reaction of (dichloroiodo)benzene with 4-aryl-1,2,3,4-tetrahydro-6- methyl-2-oxopyrimidine-5-carboxylates and 5-acetyl-4-aryl-3,4-dihydro-6- methylpyrimidin-2(1H)-ones resulted in geminal dichlorination at the C-6 methyl position of 3,4-dihydropyrimid
The development of an ecofriendly procedure for alkaline metal (II) sulfate promoted synthesis of N,N′-dimethyl substituted (unsubstituted)-4-aryl-3, 4-dihydropyrimidones (thiones) and corresponding bis-analogues in aqueous medium: evaluation by green che
Mukhopadhyay, Chhanda,Datta, Arup
experimental part, p. 136 - 146 (2010/04/23)
(Chemical Equation Presented) Different alkaline metal (II) sulfates were used as catalysts for the N,N′-dimethyl substituted as well as unsubstituted 4-aryl-3,4-dihydropyrimidones (thiones) and their corresponding bis-analogues in aqueous medium. Among t
