292870-53-2 Usage
Uses
BV02 has been used to study the effects of 14-3-3σ on P-glycoprotein and pregnane X receptor protein xpression. It has also been used as a control in studying BAP1 (BRCA1 (breast cancer gene)-associated protein 1) inducing cell death via interaction with 14-3-3 in neuroblastoma.
Biochem/physiol Actions
BV02 is an inhibitor of the 14-3-3 scaffolding proteins docking site. BV02 promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation. It induces apoptosis by c-Abl release from 14-3-3? and re-location to nuclear compartment and at mitochondrial membranes.
Check Digit Verification of cas no
The CAS Registry Mumber 292870-53-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,2,8,7 and 0 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 292870-53:
(8*2)+(7*9)+(6*2)+(5*8)+(4*7)+(3*0)+(2*5)+(1*3)=172
172 % 10 = 2
So 292870-53-2 is a valid CAS Registry Number.
292870-53-2Relevant articles and documents
Chemically stable inhibitors of 14-3-3 protein–protein interactions derived from BV02
Iralde-Lorente, Leire,Cau, Ylenia,Clementi, Letizia,Franci, Lorenzo,Tassone, Giusy,Valensin, Daniela,Mori, Mattia,Angelucci, Adriano,Chiariello, Mario,Botta, Maurizio
, p. 657 - 664 (2019)
14-3-3 are regulatory proteins that through protein–protein interactions (PPI) with numerous binding partners could be involved in several human diseases, including cancer, neurodegenerative disorders, and pathogens infections. Following our research inte
