29327-85-3Relevant academic research and scientific papers
Synthesis and study of new photochromic unsymmetrical bis-spiropyrans with nonequivalent heteroarene fragments conjugated through the common 2H,8H-pyrano[2,3-f]chromene moiety
Chernyshev, Anatoly V.,Lukyanov, Boris S.,Metelitsa, Anatoly V.,Mukhanov, Eugene L.,Ozhogin, Ilya V.,Pugachev, Artem D.
, (2020)
Four novel bis-spiropyrans possessing two different photochromic units based on indoline and 1,3-benzoxazine heterocycles which are connected through the common 2H,8H-pyrano[2,3-f]chromene moiety and modified with electron donating substituents were obtai
On the relationship between the structure and antimycobacterial activity of substituted N-benzylsalicylamides
Waisser, Karel,Perina, Milan,Klimesova, Vera,Kaustova, Jarmila
, p. 1275 - 1294 (2007/10/03)
Sixty-six N-benzylsalicylamides substituted in the acyl moiety in positions 3, 4 or 5 and in position 4 on the benzylic aromatic ring were synthesized. The compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium. To evaluate structure-antimycobacterial activity relationships (QSARs), approaches based on the Free-Wilson as well as a combination of the Free-Wilson and Hansch methods were employed (substituent constants were used to describe the influence of the benzyl substituents, indicator parameters were used for the substituents on the acyl moiety). The use of the Hammett constants for benzyl substituents was not important for QSAR equations. The quadratic representation of lipophilicity parameters (π2) was significant only in QSAR equations of antimycobacterial activity against M. avium.
