293307-41-2

Upstream product

• 104-94-9 4-methoxy-aniline 
• 137033-02-4 (+/-)-3-hydroxy-2-methylenepentanoic acid 

Downstream Products

• 293307-42-3 3-methanesulfonyl-2-methylene-N-(4-methoxyphenyl)pentanamide 
• 293307-43-4 4-ethyl-3-methylene-N-(4-methoxyphenyl)azetidin-2-one 

Relevant academic research and scientific papers

Synthesis of optically active α-methylene β-lactams through lipase-catalyzed kinetic resolution

A convenient method for the preparation of the hitherto unknown chiral α-methylene β-lactam derivatives 5a,b is reported. The optically active α-methylene β-lactams 5a-c, and their corresponding amino acids 6a-c have been readily made available through lipase-catalyzed kinetic resolution in high enantiomeric purity (up to 99% ee). The N-substituted β-lactam derivatives 4a,b and 10 are not accepted by the lipases and were prepared in optically active form by chemical transformation.

Synthesis of Optically Active α-Methylene β-Lactams through Lipase-Catalyzed Kinetic Resolution

A convenient method for the preparation of the hitherto unknown chiral α-methylene β-lactam derivatives 5a,b is reported. The optically active α-methylene β-lactams 5a-c, and their corresponding amino acids 6a-c have been readily made available through li