293329-72-3

Usage

Functional Groups

Amino (-NH2)
Oxo (C=O)
Carbonitrile (-CN)

Core Structure

Pyrano[3,2-c]chromene

Side Chain

3,4,5-trimethoxyphenyl

Potential Properties

Pharmaceutical
Medicinal

Potential Applications

Drug development

Research Status

Ongoing

Potential Uses

Treatment of various diseases and conditions

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 109-77-3 malononitrile 
• 3840-30-0 5-(chloromethyl)-1,2,3-trimethoxybenzene 
• 22105-09-5 4‐hydroxycoumarin 
• 5688-82-4 2-(3,4,5-trimethoxybenzylidene)malononitrile 

Downstream Products

• 1470027-76-9 8-amino-7-(3,4,5-trimethoxyphenyl)-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one 

Relevant academic research and scientific papers

Ni(II)-Schiff base/SBA-15: a nanostructure and reusable catalyst for one-pot three-component green synthesis of 3,4-dihydropyrano[3,2-c]chromene derivatives

An efficient, rapid, and environmentally benign Ni(II)-Schiff base/SBA-15-catalyzed one-pot three-component cyclocondensation process was described via the reaction between malononitrile, 4-hydroxycoumarin, and various aldehydes in aqueous media for the s

Synthesis of new low-viscous sulfonic acid-functionalized ionic liquid and its application as a Br?nsted liquid acid catalyst for the one-pot mechanosynthesis of 4H-pyrans through the ball milling process

In the present study, a new low-viscous sulfonic acid-functionalized ionic liquid (SAIL) viz. 4,4′-trimethylene-N,N′-sulfonic acid-dipiperidinium chloride was synthesized and characterized by FTIR, 1D and 2D NMR, and Mass spectra. Then, some properties of

Synthesis, screening and docking of fused pyrano[3,2-d]pyrimidine derivatives as xanthine oxidase inhibitor

In view of developing effective xanthine oxidase (XO) enzyme inhibitors, a series of 100 pyrano[3,2-d]pyrimidine derivatives was synthesized and evaluated for its in vitro XO enzyme inhibition. Structure activity relationship has also been established. Am

Polyethylene glycol in water: Simple, efficient, and catalyst-free synthesis of 4H-pyran derivatives

A green, one-pot, multicomponent method for the synthesis of diverse library of 4H-pyran derivatives such as 4-phenyl-4H-pyrans, spirochromenes, and dihydropyrano[3,2-c]chromines was developed using polyethylene glycol (PEG-600) as promoting reaction medi

Evaluation of Antibacterial Activities of 4-Hydroxycoumarin Derivatives

Three kinds of 4-hydroxycoumarin derivatives, namely, biscoumarins (1-4), epoxydicoumarins (5-8) and dihydropyrans (9-12), were synthesized and the antibacterial activity of each of them was evaluated. The result of preliminary bioassay shows that the low

A simple, one pot synthesis of furo[3,2-c]chromenes and evaluation of antimicrobial activity

Synthesis of a number of 2-cyano-4-oxo-3-phenyl-3,4-dihydro-2H-furo[3,2-c]chromene-2-carboxylate compounds (5) have been accomplished by a simple, multicomponent one pot reaction and evaluated for in vitro antimicrobial activity against different Gram-pos

One pot synthesis of pyran-based heterocycles from benzyl halides as key reagents

Pyridine N-oxide and silver oxide have been demonstrated to be efficient and mild reagents for the one pot synthesis of pyran analogues from a variety of benzyl halides. Benzyl halides are oxidized in situ to aldehydes, which in turn undergo a three-compo

A green one-pot three-component synthesis of tetrahydrobenzo[b]pyran and 3,4-dihydropyrano[c]chromene derivatives using a Fe3O4@SiO2-imid-PMAn magnetic nanocatalyst under ultrasonic irradiation or reflux conditi

An efficient and environmentally benign procedure for the synthesis of tetrahydrobenzo[b]pyran and 3,4-dihydropyrano[c]chromene derivatives has been developed by a one-pot three-component reaction of various aldehydes, malononitrile, and dimedone or hydro

Tris-hydroxymethylaminomethane (THAM): A novel organocatalyst for a environmentally benign synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles

A simple, efficient and environmentally benign protocol has been developed for the one-pot, multicomponent synthesis of medicinally important tetrahydrobenzo[b]pyrans and pyran-annulated heterocycles using a commercially available, inexpensive, non-toxic, and biodegradable tris-hydroxymethylaminomethane (THAM) as a novel organocatalyst. Ambient reaction conditions, wide scope, avoidance of conventional isolation as well as purification techniques and the reusability of the catalyst for five consecutive runs have improved the practical utility of this multicomponent reaction protocol manifold.

Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3′,4′:5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase

Novel hybrid derivatives of two known scaffolds; tetrahydroaminoquinoline and coumarin were synthesized and evaluated for both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities. By means of an efficient nanocatalyst, the reaction time for the syntheses of the target compounds was reduced. Subsequently, Ellman's modified method was used to evaluate the enzyme inhibitory activity of the synthesized structures. It was observed that most hybrid structures were moderate to potent inhibitors of AChE compared to Tacrine as the reference drug among which 7f with 4-fluorophenyl substituent was the most active compound (IC50 = 5 nM).