KO-612, also known as 4-(4-fluorophenyl)-1-[3-(4-methanesulfonamido)phenyl]-1,2,3,6-tetrahydropyridine, is a potent and selective inhibitor of the enzyme cyclin-dependent kinase 5 (CDK5). CDK5 plays a crucial role in various cellular processes, including neuronal function and differentiation. By inhibiting CDK5, KO-612 has been shown to have potential therapeutic applications in the treatment of neurodegenerative diseases, such as Alzheimer's disease, and other conditions where CDK5 dysregulation is implicated. The compound has been extensively studied in preclinical models, demonstrating its ability to modulate CDK5 activity and protect neurons from degeneration.
The CAS Registry Mumber 2934-02-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,3 and 4 respectively; the second part has 2 digits, 0 and 2 respectively. Calculate Digit Verification of CAS Registry Number 2934-02: (6*2)+(5*9)+(4*3)+(3*4)+(2*0)+(1*2)=83 83 % 10 = 3 So 2934-02-3 is a valid CAS Registry Number.