2936-62-1

Usage

Uses

Used in Pharmaceutical Synthesis:
(2-methylphenyl)(phenyl)methylamine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, (2-methylphenyl)(phenyl)methylamine is used as a building block in the creation of compounds designed to protect crops and enhance agricultural productivity.
Used in Organic Compounds Synthesis:
(2-methylphenyl)(phenyl)methylamine is also utilized in the synthesis of other organic compounds, highlighting its versatility in organic chemistry and its potential applications in various chemical industries.
Safety Note:
It is important to handle (2-methylphenyl)(phenyl)methylamine with caution due to its potential health hazards and reactivity, ensuring that proper safety measures are in place during its use in research and industrial applications.

InChI:InChI=1/C14H15N/c1-11-7-5-6-10-13(11)14(15)12-8-3-2-4-9-12/h2-10,14H,15H2,1H3

Upstream product

• 85515-91-9 (2-methylphenyl)phenylmethanone oxime 
• 2936-57-4 <(2-Methylphenyl)phenylmethylene>ammonium chloride 
• 131-58-8 2-Methylbenzophenone 
• 529-19-1 2-Methylbenzonitrile 
• 22627-00-5 2-methyl-benzophenone-imine 
• 21464-35-7 4-phenyl-3,4-dihydro-1H-benzo[d][1,2]oxazine; hydrochloride 

Downstream Products

• 71135-99-4 o-methylbenzhydrylurea 
• 170459-33-3 phenyl-o-tolylmethyl isocyanate 
• 49703-56-2 (RS)-(2-methylphenyl)phenylmethylamine hydrochloride 
• 132666-29-6 N-[(2-methylphenyl)(phenyl)methyl]acetamide 
• 49681-46-1 (S)-(2-methylphenyl)(phenyl)methanamine 
• 131-58-8 2-Methylbenzophenone 

Relevant academic research and scientific papers

Ruthenium-Catalyzed Direct Asymmetric Reductive Amination of Diaryl and Sterically Hindered Ketones with Ammonium Salts and H2

A Ru-catalyzed direct asymmetric reductive amination of ortho-OH-substituted diaryl and sterically hindered ketones with ammonium salts is reported. This method represents a straightforward route toward the synthesis of synthetically useful chiral primary diarylmethylamines and sterically hindered benzylamines (up to 97 % yield, 93–>99 % ee). Elaborations of the chiral amine products into bioactive compounds and a chiral ligand were demonstrated through manipulation of the removable and convertible -OH group.

Hydrogen bond directed aerobic oxidation of amines via photoredox catalysis

An application of H-bonding interactions for directing the α-C-H oxidation of amines to amides and amino-ketones catalyzed by an organic photocatalyst is reported. The high efficiency of this method is demonstrated by the aerobic oxidation of pyrrolidines, diarylamines and benzylamines bearing urea groups with high yields and a wide substrate scope.

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-reiated orphan receptor gamma (RORy) modulators and their use in the treatment of diseases mediated by RORy.

Palladium-catalyzed benzylic arylation of N-benzylxanthone imine

(Chemical Equation Presented) The direct benzylic arylation of N-benzylxanthone imine with aryl chloride proceeds under palladium catalysis, yielding the corresponding coupling product. The product is readily transformed to benzhydrylamine. Taking into consideration that the imine is readily available from benzylic amine, the overall transformation represents a formal cross-coupling reaction of aryl halide with α-aminobenzyl metal.

(Partial) agonist/antagonist properties of novel diarylalkyl carbamates on histamine H3 receptors

In the search for new ligands of the histamine H3 receptor, novel diarylalkyl carbamates (1-19 were synthesized as derivatives of 3-(1H- imidazol-4-yl)propanol and -ethanol. Carbamates were built up via isocyanates either from corresponding amines by reaction with diphosgene or from related carboxylic acid/diphenylphosphoryl azide and the alcoholic component. Sterically hindered amines were prepared in a two-step reaction sequence from corresponding ketones. Some of the title compounds showed (partial) agonist activity at the histamine H3 receptor in vitro and in vivo. Diphenylmethyl carbamate 2 was identified as a new lead structure (ED50 = 5.3 ± 2.6 mg/kg po, α = 1.0). Aromatic substitution in ortho- or para-positions of 2 led to a loss of agonist activity. meta-Substitution was tolerated to some extent. These effects seemed to be caused by steric rather than electronic properties of the substituents. An investigation of exchange of one or both phenyl rings of 2 by heterocyclic rings led to the highly active and selective thienyl derivative 18 (ED50 = 3.4 ± 1.4 mg/kg po, α = 1.0). These new (partial) agonists of the histamine H3 receptor might serve as pharmacological tools for investigating molecular aspects of the H3 receptor or as possible centrally acting therapeutic agents with oral bioavailability. (C) 2000 Elsevier Science Ltd.

Substituted benzhydryl lactamimide derivatives

Novel compounds useful as diuretic agents and anticoagulants are represented by the following formula SPC1 Wherein m is a positive whole integer of from 1 to 3; n is a positive whole integer of from 3 to 7; R and R1 may be the same or different