293732-28-2 Usage
Chemical composition
1,12-dodecano-bis(L-Ile-L-Phe) is a chemical compound made up of two molecules of the amino acid L-isoleucine and two molecules of the amino acid L-phenylalanine, connected by a dodecanoic acid linker.
Use in pharmaceutical research
It is often used as a building block in the synthesis of peptides and peptidomimetics for pharmaceutical research and drug development.
Potential applications
1,12-dodecano-bis(L-Ile-L-Phe) has potential applications in the creation of novel drugs and therapeutic agents due to its ability to mimic the structural and functional properties of naturally occurring peptides.
Research tool
It may also be used as a research tool in studying the interactions and mechanisms of action of bioactive peptides within the human body.
Structural properties
The compound has a unique structure that allows it to mimic the properties of naturally occurring peptides, making it a valuable tool in the development of new drugs and therapies.
Functional properties
1,12-dodecano-bis(L-Ile-L-Phe) has the potential to interact with various biological targets, which can be useful in the development of new drugs and therapies.
Synthesis
The compound can be synthesized through various chemical reactions, making it a versatile building block for the development of new pharmaceutical compounds.
Stability
1,12-dodecano-bis(L-Ile-L-Phe) is relatively stable, which makes it suitable for use in pharmaceutical research and drug development.
Safety
As with any chemical compound, the safety of 1,12-dodecano-bis(L-Ile-L-Phe) should be carefully evaluated before it is used in any pharmaceutical applications.
Regulatory considerations
The use of 1,12-dodecano-bis(L-Ile-L-Phe) in the development of new drugs and therapies will be subject to regulatory approval by relevant authorities, such as the FDA.
Check Digit Verification of cas no
The CAS Registry Mumber 293732-28-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,3,7,3 and 2 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 293732-28:
(8*2)+(7*9)+(6*3)+(5*7)+(4*3)+(3*2)+(2*2)+(1*8)=162
162 % 10 = 2
So 293732-28-2 is a valid CAS Registry Number.
293732-28-2Relevant academic research and scientific papers
Synthesis, conformation, and chemical properties of new mini parallel double-stranded peptides conjugated with -Phe-Phe- and - Phe-Phe-X- sequences
Kobayashi, Shigeki,Kobayashi, Hiroki,Yamaguchi, Takatoshi,Nishida, Miharu,Yamaguchi, Kentaro,Kurihara, Masaaki,Miyata, Naoki,Tanaka, Akira
, p. 920 - 934 (2007/10/03)
To investigate the chemical conformations and functions of the -Phe-Phe-Val- or -Phe-Phe- sequences contained in the Alzheimer's disease related β-amyloid peptide, a series of mini parallel double-stranded peptides conjugated with two peptide residues to one spacer were designed and prepared. The structure of the compounds was elucidated by circular dichroism (CD) spectrum and NMR two dimensional (2D) nuclear Overhauser enhancement and exchange spectroscopy (NOESY) measurments. The structure of 1,2-ethano-bis(L-Phe-L-Phe-L-Leu), 1,12-dodecano- bis(L-Phe-L-Phe-L-Leu), 1,12-dodecano-bis(L-Phe-L-Phe-L-Val), and 1,12-dodecano (D-Phe-D-Phe-D-Leu) conjugated with L-Leu and L-Val residues show a βturn-like nucleation. The dihedral angles (θ = + 75°, + 180°, ω =+ 90°, φ =- 87°, ψ =+ 180°) obtained from experimental coupling constant (J) data, etc. support that 1,12-dodecano-bis(L-Phe-L-Phe) adopts β-turn mimic nucleation. The 1,12-dodecano-bis(L-Leu-L-Leu-L-Phe), 1,12-dodecano-bis(L- Ile-L-Phe-L-Leu), and 1,12-dodecano-bis(L-Phe-L-Val-L-Leu), etc. adopt most probably a random structure by CD studies. It was found by titration spectrum that an inclusion complex of 1:1 ratio (association constant; K(a)=1.0 x l04 M-1) is formed between 1,12-dodecano-bis(L-Phe-L-Phe-L-Leu) and azobenzene (guest, [L0]=1.758 x 10-5 M-1). Moreover, the stability of the complexes was increased in order of 1,12-dodecano-bis(L-Phe- L-Phe-L-Leu) · azobenzene > 1,12-dodecano-bis(L-Phe-L-Phe-L-Val) · azobenzene > 1,12-dodecano-bis(L-Phe-L-Val-L-Leu) · azobenzene. The data show that X-Phe-L-Phe-L-spacer(S)-L-Phe-L- Phe-X (X=amino acids; S=1,2-ethano- and 1,12-dodecano-) plays an important role as a binding site of the drophobic interaction of the four Phes in the two strands is a very interesting issue in the physiological action of proteins as well as the conformation of the backbone of X-L-Phe-L-Phe-spacer(S)-L-Phe-L-Phe-X.
