293734-22-2

Upstream product

• 622-33-3 N-benzyloxyamine 
• 157659-19-3 (4R,5S)-1-cinnamoyl-3,4-dimethyl-5-phenylimidazolidin-2-one 

Downstream Products

• 293734-31-3 (4S,5R,2'S,3'R,2''S)-3-[2'-(2''-fluorenylmethoxycarbonylamino-4''-methylpentanoyl)amino-3'-hydroxy-3'-phenylpropionyl]-1,5-dimethyl-4-phenylimidazolin-2-one 
• 293734-30-2 (4R,5S,4'S,5'R,1''S)-4-[(1',5'-dimethyl-4'-phenylimidazolin-2'-on-3'-yl)carbonyl]-2-(1''-fluorenylmethoxycarbonylamino-3''-methyl-1''-butyl)-4,5-dihydro-5-phenyloxazole 
• 293734-29-9 (4S,5R,2'S,3'R)-1,5-dimethyl-4-phenyl-3-[(3'-phenyl-2'-aziridinyl)carbonyl]imidazolin-2-one 

Relevant academic research and scientific papers

Synthesis of the phenylserine - leucine dipeptide fragment present in the antibiotic lysobactin from an aziridine-2-imide precursor

The ring expansion of (2R',3S') or (2S',3R')-N-(α-amino acyl)aziridine- 2-imides and the mild hydrolysis of the resulting oxazoline-4-imides gives (2R,3S)-phenylserine-leucine or (2S,3R)-phenylserine-leucine dipeptides. In particular, the latter fragment is present in the depsipeptide antibiotic Lysobactin.