293735-38-3Relevant academic research and scientific papers
1-Aminomethylisoquinoline-4-carboxylates as novel dipeptidylpeptidase IV inhibitors
Coppola, Gary M.,Zhang, Y. Larry,Schuster, Herbert F.,Russell, Mary E.,Hughes, Thomas E.
, p. 1555 - 1558 (2000)
Structure-activity relationship within a series of 1-aminoalkylisoquinoline-4-carboxylates as inhibitors of DDP-IV is described. A primary aminomethyl group is required to maintain biological activity. Substitution of the isoquinoline at the 6- and 8-positions with methoxy groups increases potency to 53 times that of the lead compound SDZ 029-576. (C) 2000 Elsevier Science Ltd. All rights reserved.
