293751-40-3

Upstream product

• 293751-38-9 (1S,3R,4R,7S)-7-benzyloxy-3-(hypoxanthin-9-yl)-1-methanesulfonyloxymethyl-2,5-dioxabicyclo[2.2.1]heptane 
• 293751-03-8 1,2-di-O-acetyl-3-O-benzyl-4-C-methanesulfonyloxymethyl-5-O-methanesulfonyl-D-erythro-pentofuranose 
• 68-94-0 hypoxanthine 
• 293751-39-0 (1S,3R,4R,7S)-1-benzoyloxymethyl-7-benzyloxy-3-(hypoxanthin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane 

Downstream Products

• 293751-43-6 (1R,3R,4R,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(hypoxanthin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane 
• 293751-41-4 (1R,3R,4R,7S)-1-(4,4'-dimethoxytrityloxymethyl)-7-benzyloxy-3-(hypoxantin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

IMPROVED SYNTHESIS OF ?2.2.1|BICYCLO NUCLEOSIDES

A synthesis of [2.2.1]bicyclo nucleosides which is shorter and provides higher overall yields proceeds via the key intermediate of the general formula III, wherein R4 and R5 are, for instance, sulfonates and R7 is, for instance, a halogen or an acetate. F

Syntheses and base-pairing properties of locked nucleic acid nucleotides containing hypoxanthine, 2,6-diaminopurine, and 2-aminopurine nucleobases

Second generation 2′-O,4′-C-methylene-linked nucleotides 1-3 containing hypoxanthine, 2,6-diaminopurine, and 2-aminopurine nucleobases were synthesized and incorporated into locked nucleic acid (LNA) oligonucleotides by means of the automated phosphoramid