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CAS

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293753-05-6

SR3335 is a selective inverse agonist of RORα, a type of orphan nuclear receptor. It competitively inhibits the binding of 25-hydroxycholesterol to the ligand binding domain and inhibits constitutive transactivation activity. SR3335 does not affect RORβ, RORγ, farnesoid X receptor, or liver X receptor α. It induces RORα-dependent effects both in vitro and in vivo, altering gene expression and gluconeogenesis.

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  • 293753-05-6 Structure

  • Basic information

    1. Product Name: SR3335
    2. Synonyms: SR3335;SR3335,Thiophene-2-sulfonic acid [4-(2,2,2-trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenyl]-aMide;ML-176;N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-2-thiophenesulfonamide;hiophene-2-sulfonic acid [4-(2,2,2-trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenyl]-aMide
    3. CAS NO:293753-05-6
    4. Molecular Formula: C13H9F6NO3S2
    5. Molecular Weight: 405.3358792
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 293753-05-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
    8. Solubility: insoluble in H2O; ≥87.4 mg/mL in EtOH; ≥88.8 mg/mL in DMSO
    9. CAS DataBase Reference: SR3335(CAS DataBase Reference)
    10. NIST Chemistry Reference: SR3335(293753-05-6)
    11. EPA Substance Registry System: SR3335(293753-05-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 293753-05-6(Hazardous Substances Data)

293753-05-6 Usage

Uses

Used in Pharmaceutical Industry:
SR3335 is used as a selective inverse agonist for RORα, targeting the treatment of various diseases by inhibiting the binding of 25-hydroxycholesterol and altering gene expression and gluconeogenesis.
Used in Research Applications:
SR3335 is used as a research tool for studying the role of RORα in various biological processes and for investigating the potential therapeutic effects of targeting this receptor in different diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 293753-05-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,3,7,5 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 293753-05:
(8*2)+(7*9)+(6*3)+(5*7)+(4*5)+(3*3)+(2*0)+(1*5)=166
166 % 10 = 6
So 293753-05-6 is a valid CAS Registry Number.

293753-05-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]thiophene-2-sulfonamide

1.2 Other means of identification

Product number -
Other names CS-1044

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:293753-05-6 SDS

293753-05-6Downstream Products

293753-05-6Relevant articles and documents

Discovery and optimization of a series of sulfonamide inverse agonists for the retinoic acid receptor-related orphan receptor-α

Doebelin, Christelle,He, Yuanjun,Campbell, Sean,Nuhant, Philippe,Kumar, Naresh,Koenig, Marcel,Garcia-Ordonez, Ruben,Chang, Mi Ra,Roush, William R.,Lin, Li,Kahn, Susan,Cameron, Michael D.,Griffin, Patrick R.,Solt, Laura A.,Kamenecka, Theodore M.

, p. 676 - 684 (2019/10/28)

Background: Despite a massive industry endeavor to develop RORγ-modulators for autoimmune disorders, there has been no indication of efforts to target the close family member RORα for similar indications. This may be due to the misconception that RORα is

MODULATORS OF THE RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTORS

-

Page/Page column 6; 45; 46, (2011/10/10)

The invention provides small molecule modulators of retinoic acid receptor-related orphan receptors such as RORα RORβ, or RORγ. Compounds of the invention can be effective modulators at concentrations ineffective to act on LXR receptors, or on other nuclear receptors, or other biological targets. Methods of modulation the RORs and methods of treating metabolic disorders, immune disorders, cancer, and CNS disorders wherein modulation of an ROR is medically indicated are also provided.

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