293753-05-6 Usage
Description
The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles. SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM). It is without effect on RORβ, RORγ, farnesoid X receptor, or liver X receptor α. SR 3335 evokes RORα-dependent effects both in vitro and in vivo, altering gene expression as well as gluconeogenesis.
Check Digit Verification of cas no
The CAS Registry Mumber 293753-05-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,3,7,5 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 293753-05:
(8*2)+(7*9)+(6*3)+(5*7)+(4*5)+(3*3)+(2*0)+(1*5)=166
166 % 10 = 6
So 293753-05-6 is a valid CAS Registry Number.
293753-05-6Relevant articles and documents
Discovery and optimization of a series of sulfonamide inverse agonists for the retinoic acid receptor-related orphan receptor-α
Doebelin, Christelle,He, Yuanjun,Campbell, Sean,Nuhant, Philippe,Kumar, Naresh,Koenig, Marcel,Garcia-Ordonez, Ruben,Chang, Mi Ra,Roush, William R.,Lin, Li,Kahn, Susan,Cameron, Michael D.,Griffin, Patrick R.,Solt, Laura A.,Kamenecka, Theodore M.
, p. 676 - 684 (2019/10/28)
Background: Despite a massive industry endeavor to develop RORγ-modulators for autoimmune disorders, there has been no indication of efforts to target the close family member RORα for similar indications. This may be due to the misconception that RORα is
