293758-78-8

Basic information

• Product Name: 4-(tert-butyl-dimethyl-silanoxy)-3-(3-methoxycarbonyl-phenylsulfanylmethyl)-indazole-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(tert-butyl-dimethyl-silanoxy)-3-(3-methoxycarbonyl-phenylsulfanylmethyl)-indazole-1-carboxylic acid tert-butyl ester
• CAS NO: 293758-78-8
• Molecular Weight: 528.745
• Mol File: 293758-78-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(tert-butyl-dimethyl-silanoxy)-3-(3-methoxycarbonyl-phenylsulfanylmethyl)-indazole-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(tert-butyl-dimethyl-silanoxy)-3-(3-methoxycarbonyl-phenylsulfanylmethyl)-indazole-1-carboxylic acid tert-butyl ester(293758-78-8)
• EPA Substance Registry System: 4-(tert-butyl-dimethyl-silanoxy)-3-(3-methoxycarbonyl-phenylsulfanylmethyl)-indazole-1-carboxylic acid tert-butyl ester(293758-78-8)

Safety Data

• Hazardous Substances Data: 293758-78-8(Hazardous Substances Data)

Upstream product

• 72886-42-1 methyl 3-sulfanylbenzoate 
• 293758-73-3 3-bromomethyl-4-(tert-butyl-dimethyl-silanoxy)-indazole-1-carboxylic acid tert-butyl ester 
• 699-83-2 2,6-dihydroxylacetophenone 
• 4869-59-4 3-mercapto benzoic acid 
• 149071-05-6 3-methyl-4-hydroxyindazole 
• 293758-71-1 4-(tert-butyl-dimethyl-silanoxy)-3-methyl-1H-indazole 
• 293758-72-2 4-(tert-butyl-dimethyl-silanoxy)-3-methyl-indazole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 293758-79-9 4-benzyloxy-3-(3-methoxycarbonyl-phenylsulfanylmethyl)-indazole-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening

Random screening provided no suitable lead structures in a search for novel inhibitors of the bacterial enzyme DNA gyrase. Therefore, an alternative approach had to be developed. Relying on the detailed 3D structural information of the targeted ATP bindin