293759-48-5Relevant academic research and scientific papers
Metal-Free C-C Coupling of an Allenyl Sulfone with Picolyl Amides to Access Vinyl Sulfones via Pyridine-Initiated in Situ Generation of Sulfinate Anion
Omer, Humair M.,Liu, Peng,Brummond, Kay M.
, p. 7959 - 7975 (2020/07/15)
Vinyl sulfones are privileged motifs known for their biological activity and synthetic utility. Synthetic transformations to efficiently access high-value compounds with these motifs are desired and sought after. Herein, a new procedure is described to fo
Cobalt-catalyzed carbonylative synthesis of phthalimides from n-(pyridin-2-ylmethyl)benzamides with tfben as the co source
Fu, Lu-Yang,Wu, Xiao-Feng,Ying, Jun
, (2019/10/08)
A cobalt-catalyzed direct carbonylative synthesis of phthalimide motifs from N-(pyridin-2-ylmethyl)benzamides has been developed. Various phthalimide derivatives were obtained in moderate to excellent yields (up to 98percent) by using 2-picolylamine as an efficient directing group and benzene-1,3,5-triyl triformate (TFBen) as a convenient CO surrogate.
Combining metabolite-based pharmacophores with Bayesian machine learning models for mycobacterium tuberculosis drug discovery
Ekins, Sean,Madrid, Peter B.,Sarker, Malabika,Li, Shao-Gang,Mittal, Nisha,Kumar, Pradeep,Wang, Xin,Stratton, Thomas P.,Zimmerman, Matthew,Talcott, Carolyn,Bourbon, Pauline,Travers, Mike,Yadav, Maneesh,Freundlich, Joel S.
, (2015/12/26)
Integrated computational approaches for Mycobacterium tuberculosis (Mtb) are useful to identify new molecules that could lead to future tuberculosis (TB) drugs. Our approach uses information derived from the TBCyc pathway and genome database, the Collabor
Synthesis and anticancer activity of oxindole derived imidazo[1,5-a] pyrazines
Kamal, Ahmed,Ramakrishna,Raju,Rao, A.V. Subba,Viswanath,Nayak, V. Lakshma,Ramakrishna, Sistla
experimental part, p. 2427 - 2435 (2011/06/24)
A series of oxindole derivatives of imidazo[1,5-a]pyrazines were prepared and confirmed by 1H NMR, mass and HRMS data. These compounds were evaluated for their anticancer activity against a panel of 52 human tumor cell lines derived from nine d
