29378-19-6Relevant academic research and scientific papers
METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY
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Page/Page column 10; 41, (2009/04/24)
Disclosed are compositions which modulate the interaction with nerve growth factor and precursors thereof with neurotrophic receptors. Also disclosed are methods of using the compositions of the invention, including methods of administration.
Method of inhibiting binding of nerve growth factor to p75 NTR receptor
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, (2008/06/13)
The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75NTRcommon neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor to p75NTRcomprises, particularly when bound to nerve growth factor, at least two of the following: (1) a first electronegative atom or functional group positioned to interact with Lys34of nerve growth factor; (2) a second electronegative atom or functional group positioned to interact with Lys95of nerve growth factor; (3) a third electronegative atom or functional group positioned to interact with Lys88of nerve growth factor; (4) a fourth electronegative atom or functional group positioned to interact with Lys32of nerve growth factor; and (5) a hydrophobic moiety which interacts with the hydrophobic region formed by Ile31, Phe101and Phe86of nerve growth factor.
Hydrolytically degradable amino acid containing polymers
Staubli, Andrea,Ron, Eyal,Langer, Robert
, p. 4419 - 4424 (2007/10/02)
A universal approach to incorporate amino acids into a polymeric backbone via hydrolytically labile bonds is reported. The amino acids were first converted into dicarboxylic acids by derivatization at their amino terminus with trimellitic anhydride and su
