2940-24-1

Usage

Chemical class

Synthetic organic compound

Chemical structure

Contains a 1,3-oxazole ring, a phenyl group with a methoxy substituent, and a carboxylic acid functional group

Usage

Pharmaceutical research and drug development

Purpose

Potential intermediate or building block for the synthesis of new compounds with potential biological activities

Structure implications

Ability to interact with specific biological targets

Value

Valuable starting material for the development of new pharmaceuticals with potential therapeutic applications

Upstream product

• 1084941-03-6 methyl 2-(4-methoxyphenyl)-5-methyloxazole-4-carboxylate 
• 124811-87-6 ethyl 2-(4-methoxyphenyl)-5-methyloxazole-4-carboxylate 
• 18805-35-1 1-[2-(4-methoxy-phenyl)-5-methyl-3-oxy-oxazol-4-yl]-ethanone; hydrochloride 
• 3222-92-2 1-[2-(4-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]ethanone 

Downstream Products

• 845782-60-7 2-(4-methoxy-phenyl)-5-methyl-oxazole-4-carboxylic acid chloride 

Relevant academic research and scientific papers

Towards Gram-negative antivirulence drugs: New inhibitors of HldE kinase

Gram-negative bacteria lacking heptoses in their lipopolysaccharide (LPS) display attenuated virulence and increased sensitivity to human serum and to some antibiotics. Thus inhibition of bacterial heptose synthesis represents an attractive target for the development of new antibacterial agents. HldE is a bifunctional enzyme involved in the synthesis of bacterial heptoses. Development of a biochemical assay suitable for high-throughput screening allowed the discovery of inhibitors 1 and 2 of HldE kinase. Study of the structure-activity relationship of this series of inhibitors led to highly potent compounds.

Di-heterocyclic compounds and their use as antiviral agents

Compounds of the formulas: STR1 wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are useful as antiviral agents, especially against picornaviruses. N-(Chloroalkyl)amide intermediates for the compounds of Formula I are also active as antiviral agents. Related compounds outside the scope of the above formulas are also disclosed.