2940-98-9Relevant academic research and scientific papers
Reduction of β-Lactams,III. Synthesis of β-Thiolactams and Reduction with Raney Nickel
Verkoyen, Carl,Rademacher, Paul
, p. 653 - 660 (2007/10/02)
The N-substituted β-lactams 1-3 react with P2S5 or Lawesson reagent (11) to give the β-thiolactams 5-7.The bi-β-lactam 4 is transformed by 11 to the bi-β-thiolactam 8, with P2S5 however rearrangement occurs to the bicyclic thiohydrazide 10. - Reduction wi
Reduction of β-Lactams, I. Reduction of 3,3,3',3'-Tetramethyl-2,2'-dione with Complex Hydrides
Verkoyen, Carl,Rademacher, Paul
, p. 1659 - 1670 (2007/10/02)
Reduction of the title compound 7 with lithium aluminium hydride leads to four products 8 to 11 in yields depending on the reaction conditions.Compounds 8 to 10 are also obtained from the bicyclic hydrazide 12, isomeric with 7.Therefore, the reduction of 7 and 12 is likely to proceed in part via common intermediates.A reaction scheme is proposed to account for the generation of the products.With other hydride reagents comlex reaction mixtures are obtained from 7.The reduction of 7 to 3,3,3',3'-tetramethyl-1,1'-biazetidine (13) failed.
